国际眼科杂志
國際眼科雜誌
국제안과잡지
International Eye Science
2015年
12期
2055-2059
,共5页
鲁军霞%林红%王芬%林静%张丽娜%赵桂秋
魯軍霞%林紅%王芬%林靜%張麗娜%趙桂鞦
로군하%림홍%왕분%림정%장려나%조계추
Livin%Caspase-3%眼部淋巴瘤%反应性淋巴组织增生
Livin%Caspase-3%眼部淋巴瘤%反應性淋巴組織增生
Livin%Caspase-3%안부림파류%반응성림파조직증생
Livin%Caspase -3%ocular lymphoma%reactive lymphoid tissue hyperplasia
目的：探讨眼附属器淋巴组织增生性病变组织中Livin和Caspase－3的表达情况及临床意义。<br> 方法：收集1995－06／2015－06青岛大学附属医院眼科病理室石蜡包埋标本，采用免疫组化法检测40例眼部B细胞非霍奇金淋巴瘤（ non－Hodgkin lymphoma，NHL）、10例反应性淋巴组织增生组织中Livin和Caspase－3的表达情况，以患者的年龄、性别、发病部位、病理类型分级作为眼附属器淋巴瘤的分类标准。<br> 结果：Livin及Caspase－3的表达与年龄、性别及发病部位无关，而与病理分级有关，Livin在淋巴瘤中的表达率显著高于反应性淋巴组织增生组织（P＜0．05），且随着病理分级恶性程度的增加其表达逐渐上升（ P＜0．05）；Caspase－3在淋巴瘤中的表达率则显著低于反应性淋巴组织增生（P＜0．05），且随病理分级的增加其表达逐渐降低（P＜0．05）。在NHL中，Livin和Caspase－3两者的表达呈负相关（ r＝－0．491，χ2＝7．519，P＜0．05）。<br> 结论：过量的Livin表达及Caspase－3的低表达可能与眼部淋巴瘤的发生有关，且在NHL中两者表现为负相关，联合检测两种蛋白对眼部B细胞淋巴瘤的临床表现及病理分型有重要意义。
目的：探討眼附屬器淋巴組織增生性病變組織中Livin和Caspase－3的錶達情況及臨床意義。<br> 方法：收集1995－06／2015－06青島大學附屬醫院眼科病理室石蠟包埋標本，採用免疫組化法檢測40例眼部B細胞非霍奇金淋巴瘤（ non－Hodgkin lymphoma，NHL）、10例反應性淋巴組織增生組織中Livin和Caspase－3的錶達情況，以患者的年齡、性彆、髮病部位、病理類型分級作為眼附屬器淋巴瘤的分類標準。<br> 結果：Livin及Caspase－3的錶達與年齡、性彆及髮病部位無關，而與病理分級有關，Livin在淋巴瘤中的錶達率顯著高于反應性淋巴組織增生組織（P＜0．05），且隨著病理分級噁性程度的增加其錶達逐漸上升（ P＜0．05）；Caspase－3在淋巴瘤中的錶達率則顯著低于反應性淋巴組織增生（P＜0．05），且隨病理分級的增加其錶達逐漸降低（P＜0．05）。在NHL中，Livin和Caspase－3兩者的錶達呈負相關（ r＝－0．491，χ2＝7．519，P＜0．05）。<br> 結論：過量的Livin錶達及Caspase－3的低錶達可能與眼部淋巴瘤的髮生有關，且在NHL中兩者錶現為負相關，聯閤檢測兩種蛋白對眼部B細胞淋巴瘤的臨床錶現及病理分型有重要意義。
목적：탐토안부속기림파조직증생성병변조직중Livin화Caspase－3적표체정황급림상의의。<br> 방법：수집1995－06／2015－06청도대학부속의원안과병리실석사포매표본，채용면역조화법검측40례안부B세포비곽기금림파류（ non－Hodgkin lymphoma，NHL）、10례반응성림파조직증생조직중Livin화Caspase－3적표체정황，이환자적년령、성별、발병부위、병리류형분급작위안부속기림파류적분류표준。<br> 결과：Livin급Caspase－3적표체여년령、성별급발병부위무관，이여병리분급유관，Livin재림파류중적표체솔현저고우반응성림파조직증생조직（P＜0．05），차수착병리분급악성정도적증가기표체축점상승（ P＜0．05）；Caspase－3재림파류중적표체솔칙현저저우반응성림파조직증생（P＜0．05），차수병리분급적증가기표체축점강저（P＜0．05）。재NHL중，Livin화Caspase－3량자적표체정부상관（ r＝－0．491，χ2＝7．519，P＜0．05）。<br> 결론：과량적Livin표체급Caspase－3적저표체가능여안부림파류적발생유관，차재NHL중량자표현위부상관，연합검측량충단백대안부B세포림파류적림상표현급병리분형유중요의의。
?AIM:To investigate the expression of Livin and Caspase-3 proteins in ocular adnexal lymphoproliferative lesions and its clinical significance. <br> ?METHODS:Patients suffering from B-cell non-Hodgkin lymphoma( NHL) ( n=40 ) and reactive lymphoid tissue hyperplasia(RLH) ( n=10) of ocular adnexal from June 1995 to June 2015 in Qingdao Affiliated Hospital were observed and the 50 paraffin sections were collected.RLH sections were selected to the control group.The patients'age, gender, pathogenic site and pathological types were selected as the classification criteria.The expression of Livin and Caspase -3 proteins were detected by immunohistochemistry and the positive expression rate between lymphomas and RLH was compared.Spearman rank correlation was used to estimate the relationbetween Livin and Caspase-3 in ocular adnexal lymphoma. <br> ?RESULTS:The expression of Caspase-3 in B-cell NHL was lower than that in lymphadenosis (P<0.05).While the expression of Livin in NHL was higher (P<0.05).The two proteins had no relation with the age, pathogenic site or gender.But they were related to pathologic type.Livin was highly increased in plasmacytoma ( PL) and diffused large B-cell lymphoma( DLBCL) compared with mucosa-associated lymphoid tissue(MALT) lymphoma(P<0.05). While Caspase-3 in PL and DLBCL were lower than that in MALT lymphoma ( P <0.05 ) . There was a negative correlation between Livin and Caspase-3 in MALT( r=-0.491,χ2=7.519,P<0.05). <br> ? CONCLUSION: Over expression of Livin and low expression of Caspase-3 may play a significant role in the occurrence, development and different pathologic type of ocular lymphoma.The expression of Livin and Caspase-3 combined with each other in NHL.Combined examination of two proteins may be a valuable marker to predict the presence and differentiate the pathologic type of ocular adnexal lymphomas.
