临床荟萃
臨床薈萃
림상회췌
Clinical Focus
2015年
12期
1410-1412
,共3页
糖尿病肾病%蛋白尿%前列地尔%血塞通注射液
糖尿病腎病%蛋白尿%前列地爾%血塞通註射液
당뇨병신병%단백뇨%전렬지이%혈새통주사액
diabetic nephropathies%proteinuria%alprostadil%sanqi panaxnotoginseng
目的：探讨短期静脉应用前列地尔联合血塞通注射液对早期糖尿病肾病患者肾功能及尿蛋白的影响。方法选取血糖、血压稳定的早期糖尿病肾病患者85例,随机分为对照组20例、前列地尔(凯时)组20例、血塞通组22例、前列地尔联合血塞通(联合)组23例。凯时组予以凯时10μg,每日1次,连续14天；血塞通组静脉滴注血塞通注射液4 ml(加入木糖醇注射液250 ml),每日1次,连续14天；联合组静脉给予凯时10μg 及血塞通注射液4 ml,每日1次,连续14天；对照组只给予对症治疗,包括控制血糖、血压、血脂等基本治疗方法各组相同。结果凯时组、血塞通组及联合组治疗后尿总蛋白、微量白蛋白和血、尿β2微球蛋白均明显下降(P <0.05)。与对照组比较,凯时组、血塞通注射液组及联合组患者24小时尿总蛋白、微量白蛋白和尿β2微球蛋白明显降低(P <0.01),凯时组、血塞通组血β2微球蛋白明显降低(P <0.05),联合组血β2微球蛋白降低更明显(P <0.01)。联合组尿总蛋白、微量白蛋白、血、尿β2微球蛋白较凯时组和血塞通注射液组均明显降低(P <0.05)。结论前列地尔与血塞通注射液短期静脉应用均能明显降低早期糖尿病肾病患者尿蛋白,但二者联合应用疗效更显著,但对尿素氮及肌酐无明显影响。
目的：探討短期靜脈應用前列地爾聯閤血塞通註射液對早期糖尿病腎病患者腎功能及尿蛋白的影響。方法選取血糖、血壓穩定的早期糖尿病腎病患者85例,隨機分為對照組20例、前列地爾(凱時)組20例、血塞通組22例、前列地爾聯閤血塞通(聯閤)組23例。凱時組予以凱時10μg,每日1次,連續14天；血塞通組靜脈滴註血塞通註射液4 ml(加入木糖醇註射液250 ml),每日1次,連續14天；聯閤組靜脈給予凱時10μg 及血塞通註射液4 ml,每日1次,連續14天；對照組隻給予對癥治療,包括控製血糖、血壓、血脂等基本治療方法各組相同。結果凱時組、血塞通組及聯閤組治療後尿總蛋白、微量白蛋白和血、尿β2微毬蛋白均明顯下降(P <0.05)。與對照組比較,凱時組、血塞通註射液組及聯閤組患者24小時尿總蛋白、微量白蛋白和尿β2微毬蛋白明顯降低(P <0.01),凱時組、血塞通組血β2微毬蛋白明顯降低(P <0.05),聯閤組血β2微毬蛋白降低更明顯(P <0.01)。聯閤組尿總蛋白、微量白蛋白、血、尿β2微毬蛋白較凱時組和血塞通註射液組均明顯降低(P <0.05)。結論前列地爾與血塞通註射液短期靜脈應用均能明顯降低早期糖尿病腎病患者尿蛋白,但二者聯閤應用療效更顯著,但對尿素氮及肌酐無明顯影響。
목적：탐토단기정맥응용전렬지이연합혈새통주사액대조기당뇨병신병환자신공능급뇨단백적영향。방법선취혈당、혈압은정적조기당뇨병신병환자85례,수궤분위대조조20례、전렬지이(개시)조20례、혈새통조22례、전렬지이연합혈새통(연합)조23례。개시조여이개시10μg,매일1차,련속14천；혈새통조정맥적주혈새통주사액4 ml(가입목당순주사액250 ml),매일1차,련속14천；연합조정맥급여개시10μg 급혈새통주사액4 ml,매일1차,련속14천；대조조지급여대증치료,포괄공제혈당、혈압、혈지등기본치료방법각조상동。결과개시조、혈새통조급연합조치료후뇨총단백、미량백단백화혈、뇨β2미구단백균명현하강(P <0.05)。여대조조비교,개시조、혈새통주사액조급연합조환자24소시뇨총단백、미량백단백화뇨β2미구단백명현강저(P <0.01),개시조、혈새통조혈β2미구단백명현강저(P <0.05),연합조혈β2미구단백강저경명현(P <0.01)。연합조뇨총단백、미량백단백、혈、뇨β2미구단백교개시조화혈새통주사액조균명현강저(P <0.05)。결론전렬지이여혈새통주사액단기정맥응용균능명현강저조기당뇨병신병환자뇨단백,단이자연합응용료효경현저,단대뇨소담급기항무명현영향。
ABSTRACT:Objective To observe the effect of alprostadil combined with Sanqi Panax Notoginseng Injection on renal function and proteinuria in early diabetic nephropathy.Methods A total of 85 patients with early diabetic nephropathy were divided randomly into four groups,including 20 patients in control group,20 patients treated with alprostadil 10 μg daily for 14 days,22 patients treated with Sanqi Panax Notoginseng Injection 4 ml daily for 14 days and 23 patients treated with alprostadil 10 μg combined with Sanqi Panax Notoginseng Injection 4 ml daily for 14 days. The control group only got management of blood glucose,blood pressure and blood lipid.Results In the treating group (alprostadil group,Sanqi Panax Notoginseng Injection group and the combination treatment group),the levels of 24-h urinary proteinuria,microalbuminuria,blood and urine β2-MG significantly reduced after treatment (P <0.05 ).In the treating group,the levels of 24-h urinary proteinuria,microalbuminuria and urine β2-MG significantly reduced as compared with the control group (P < 0.01 );Blood β2-MG also significantly reduced in the alprostadil group and Sanqi Panax Notoginseng Injection group than in the control group (P <0.05),and more reduced in the combination treatment group (P < 0.01 ); In the combination treatment group, the levels of 24-h urinary proteinuria, microalbuminuria,blood and urine β2-MG were significantly decreased as compared with alprostadil and Sanqi Panax Notoginseng Injection group (P < 0.05 ).Conclusion Both alprostadil and Sanqi Panax Notoginseng Injection may decrease proteinuria in patients with early diabetic nephropathy,while combination treatment may be more prominent but without significant effect on the urea nitrogen and creatinine.
