中国基层医药
中國基層醫藥
중국기층의약
Chinese Journal of Primary Medicine and Pharmacy
2015年
22期
3454-3456
,共3页
消化性溃疡%幽门螺杆菌%四联疗法%三联疗法
消化性潰瘍%幽門螺桿菌%四聯療法%三聯療法
소화성궤양%유문라간균%사련요법%삼련요법
Peptic ulcer%Helicobacter pylori%Quadruple therapy%Triple therapy
目的：比较四联疗法与三联疗法治疗幽门螺杆菌（Hp）阳性消化性溃疡的疗效。方法选取幽门螺杆菌相关性消化性溃疡62例，以随机数字表法分为观察组32例和对照组30例。对照组给予三联疗法（兰索拉唑＋克拉霉素＋阿莫西林）治疗，观察组给予四联疗法（兰索拉唑＋克拉霉素＋阿莫西林＋胶体果胶铋）治疗，观察比较两组临床疗效、溃疡愈合率、Hp 根除率及不良反应发生率。结果观察组临床效果优于对照组（缓解率96．88％比83．33％），差异有统计学意义（χ2＝21．44，P ＜0．05）；观察组 Hp 根除率高于对照组（93．75％比76．67％．）（χ2＝49．56，P ＜0．05），溃疡愈合率高于对照组（P ＞0．05）；两组不良反应发生率差异无统计学意义（P ＞0．05）。结论四联疗法治疗 Hp 阳性消化性溃疡具有较好疗效，未增加不良反应发生率，值得推广应用。
目的：比較四聯療法與三聯療法治療幽門螺桿菌（Hp）暘性消化性潰瘍的療效。方法選取幽門螺桿菌相關性消化性潰瘍62例，以隨機數字錶法分為觀察組32例和對照組30例。對照組給予三聯療法（蘭索拉唑＋剋拉黴素＋阿莫西林）治療，觀察組給予四聯療法（蘭索拉唑＋剋拉黴素＋阿莫西林＋膠體果膠鉍）治療，觀察比較兩組臨床療效、潰瘍愈閤率、Hp 根除率及不良反應髮生率。結果觀察組臨床效果優于對照組（緩解率96．88％比83．33％），差異有統計學意義（χ2＝21．44，P ＜0．05）；觀察組 Hp 根除率高于對照組（93．75％比76．67％．）（χ2＝49．56，P ＜0．05），潰瘍愈閤率高于對照組（P ＞0．05）；兩組不良反應髮生率差異無統計學意義（P ＞0．05）。結論四聯療法治療 Hp 暘性消化性潰瘍具有較好療效，未增加不良反應髮生率，值得推廣應用。
목적：비교사련요법여삼련요법치료유문라간균（Hp）양성소화성궤양적료효。방법선취유문라간균상관성소화성궤양62례，이수궤수자표법분위관찰조32례화대조조30례。대조조급여삼련요법（란색랍서＋극랍매소＋아막서림）치료，관찰조급여사련요법（란색랍서＋극랍매소＋아막서림＋효체과효필）치료，관찰비교량조림상료효、궤양유합솔、Hp 근제솔급불량반응발생솔。결과관찰조림상효과우우대조조（완해솔96．88％비83．33％），차이유통계학의의（χ2＝21．44，P ＜0．05）；관찰조 Hp 근제솔고우대조조（93．75％비76．67％．）（χ2＝49．56，P ＜0．05），궤양유합솔고우대조조（P ＞0．05）；량조불량반응발생솔차이무통계학의의（P ＞0．05）。결론사련요법치료 Hp 양성소화성궤양구유교호료효，미증가불량반응발생솔，치득추엄응용。
Objective To compare the curative effect of quadruple therapy and triple therapy for Helicobact-er pylori positive peptic ulcer.Methods 62 patients with Helicobacter pylori positive peptic ulcer were randomly devided into observation group(32 cases)and control group(30 cases).Patients in the control group were treated with triple therapy (lansoprazole,amoxicillin,clarithromycin),while the observation group was given quadruple therapy (lansoprazole,amoxicillin,clarithromycin,colloidal bismmth pectin).The clinical efficacy,ulcer healing rate,H.pylori eradication rate and adverse reaction rate of the two groups were observed and compared.Results The clinical effect of the observation group was better than the control group(remission rate 96.88% vs.83.33%),the difference was significant (χ2 =21.44,P <0.05).The H.pylori eradication rate in the observation group was higher than that in the control group (93.75% vs 76.67%)(χ2 =49.56,P <0.05).The ulcer healing rate in the observation group was higher than that of the control group(P >0.05).The incidence of adverse reactions between the two groups had no statistically significant difference (P >0.05).Conclusion Quadruple therapy in the treatment of H.pylori positive peptic ulcer has good curative effect,did not increase the incidence of adverse reactions.It is worthy of popularization and application.
