南京晓庄学院学报
南京曉莊學院學報
남경효장학원학보
Journal of Nanjing Xiaozhuang University
2015年
6期
7-9
,共3页
潘兆瑞%石翛然%邵阳%刘雪茹%莫正靖
潘兆瑞%石翛然%邵暘%劉雪茹%莫正靖
반조서%석소연%소양%류설여%막정정
咔唑%Suzuki%偶联反应%3 ,6-二吡啶N-乙基咔唑
咔唑%Suzuki%偶聯反應%3 ,6-二吡啶N-乙基咔唑
잡서%Suzuki%우련반응%3 ,6-이필정N-을기잡서
carbazole%Suzuki coupling reaction%9-Ethyl-3,6-di-pyridin-4-yl-9 H-carbazole
该文以咔唑为原料,利用Suzuki偶联反应成功合成了3,6-二吡啶N-乙基咔唑.咔唑首先与溴乙烷发生取代反应生成N-乙基咔唑,然后与N-溴代丁二酰亚胺反应生成3,6-二溴代N-乙基咔唑,最后与吡啶-4-硼酸通过Suzuki偶联反应生成目标化合物.三步反应总收率为55.7%,并对目标产物进行了红外和核磁表征.
該文以咔唑為原料,利用Suzuki偶聯反應成功閤成瞭3,6-二吡啶N-乙基咔唑.咔唑首先與溴乙烷髮生取代反應生成N-乙基咔唑,然後與N-溴代丁二酰亞胺反應生成3,6-二溴代N-乙基咔唑,最後與吡啶-4-硼痠通過Suzuki偶聯反應生成目標化閤物.三步反應總收率為55.7%,併對目標產物進行瞭紅外和覈磁錶徵.
해문이잡서위원료,이용Suzuki우련반응성공합성료3,6-이필정N-을기잡서.잡서수선여추을완발생취대반응생성N-을기잡서,연후여N-추대정이선아알반응생성3,6-이추대N-을기잡서,최후여필정-4-붕산통과Suzuki우련반응생성목표화합물.삼보반응총수솔위55.7%,병대목표산물진행료홍외화핵자표정.
In this paper, 9-Ethyl-3,6-di-pyridin-4-yl-9H-Carbazole was synthesized by the method of Suzuki cou-pling reaction with carbazole as raw materials. Firstly, N-ethyl carbazole was generated by the substitution reaction of Carbazole with bromine ethane, Then the obtained product reacted with N-bromosuccinimide and generated 3,6-dibromo-N-ethyl carbazole. Finally the target compound was obtained by Suzuki coupling reaction of 3,6-dibromo-N-ethyl carbazole with pyridine-4-boric acid. The total yield was 55. 7%, and the target compound was character-ized with 1 H NMR.