CAJ | 학술논문

目的：通过受试者工作特征曲线（ROC 曲线）分析，确定利用即刻法与孵育后活化部分凝血活酶时间（APTT ）结果差值预测血友病 A 凝血因子Ⅷ抑制物产生的临界诊断点。方法回顾分析172例血友病 A 患儿的APTT 纠正试验及抑制物定量监测结果，并应用 ROC 曲线分析血友病 A 凝血因子Ⅷ抑制物阳性的最佳临界点。结果 ROC 曲线下面积＝0．908（95％ CI ：0．875～0．941，P ＜0．05），Youden 值为0．679，所对应的 APTT 差值为2．6 s ，为有无抑制物的最佳诊断界点。此时敏感度为80．4％，诊断特异度为87．5％。结论2．6 s 的 APTT 纠正试验秒值差可作为儿童血友病 A 凝血因子Ⅷ抑制物产生的早期筛查指标。
목적：통과수시자공작특정곡선（ROC 곡선）분석，학정이용즉각법여부육후활화부분응혈활매시간（APTT ）결과차치예측혈우병 A 응혈인자Ⅷ억제물산생적림계진단점。방법회고분석172례혈우병 A 환인적APTT 규정시험급억제물정량감측결과，병응용 ROC 곡선분석혈우병 A 응혈인자Ⅷ억제물양성적최가림계점。결과 ROC 곡선하면적＝0．908（95％ CI ：0．875～0．941，P ＜0．05），Youden 치위0．679，소대응적 APTT 차치위2．6 s ，위유무억제물적최가진단계점。차시민감도위80．4％，진단특이도위87．5％。결론2．6 s 적 APTT 규정시험초치차가작위인동혈우병 A 응혈인자Ⅷ억제물산생적조기사사지표。
Objective To predict the critical diagnosis point of F Ⅷ inhibitor through determining the differ‐ence between immediate and incubated APTT results by ROC curve analysis .Methods To retrospectively analyze the quantitative results of APTT correction and F Ⅷ inhibitor experiment in 172 cases of HA children .And to analyze the best of critical positive point of F Ⅷ inhibitor by ROC curve .Results The area under the ROC curve (AUC) was 0 .908(95% CI :0 .875 - 0 .941 ,P< 0 .05) and Youden value was 0 .679 .The corresponding difference of APT T (2 .6 s) was the best diagnostic cutoff point for predicting F Ⅷ inhibitors .The sensitivity was 80 .4% and the specificity was 87 .5% for predicting F Ⅷ inhibitors .Conclusion The time difference (2 .6 s) of APTT correcting test can pro‐vide a reference and predictive indicator for early diagnosis of F Ⅷ inhibitor development in children with HA .