湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
Journal of Hunan Normal University (Medical Science)
2015年
5期
32-34,35
,共4页
叶酸%H型高血压%高同型半胱氨酸血症%心血管事件%疗效观察
葉痠%H型高血壓%高同型半胱氨痠血癥%心血管事件%療效觀察
협산%H형고혈압%고동형반광안산혈증%심혈관사건%료효관찰
folic acid%H type hypertension%homocysteine%cardiovascular events%curative effect observation
目的：观察和分析叶酸干预治疗对H型老年高血压患者同型半胱氨酸（Hcy）水平和心血管事件（MACE）发生风险的影响。方法：选取200例老年H型高血压患者作为研究对象，将其随机分为观察组和对照组，每组各100例，对照组患者给予常规降压治疗，观察组患者在常规降压治疗的基础上加用叶酸干预治疗。对两组患者治疗前、后的血浆Hcy水平进行检测和比较；随访两组患者，对两组患者随访期内MACE发生情况进行观察和比较。结果：观察组患者治疗后的血浆Hcy水平较治疗前显著下降，其治疗后的血浆Hcy水平显著低于对照组，MACE总发生率和脑卒中发病率显著低于对照组，患者发生MACE与病程（OR=1.438）、治疗前血浆Hcy水平（OR=2.034）和治疗后血浆Hcy水平（OR=2.869）具有相关性。结论：针对老年H型高血压患者，在常规降压治疗的同时应用叶酸干预治疗，可显著降低患者的血浆Hcy水平和MACE发生风险，有助于改善患者的预后。
目的：觀察和分析葉痠榦預治療對H型老年高血壓患者同型半胱氨痠（Hcy）水平和心血管事件（MACE）髮生風險的影響。方法：選取200例老年H型高血壓患者作為研究對象，將其隨機分為觀察組和對照組，每組各100例，對照組患者給予常規降壓治療，觀察組患者在常規降壓治療的基礎上加用葉痠榦預治療。對兩組患者治療前、後的血漿Hcy水平進行檢測和比較；隨訪兩組患者，對兩組患者隨訪期內MACE髮生情況進行觀察和比較。結果：觀察組患者治療後的血漿Hcy水平較治療前顯著下降，其治療後的血漿Hcy水平顯著低于對照組，MACE總髮生率和腦卒中髮病率顯著低于對照組，患者髮生MACE與病程（OR=1.438）、治療前血漿Hcy水平（OR=2.034）和治療後血漿Hcy水平（OR=2.869）具有相關性。結論：針對老年H型高血壓患者，在常規降壓治療的同時應用葉痠榦預治療，可顯著降低患者的血漿Hcy水平和MACE髮生風險，有助于改善患者的預後。
목적：관찰화분석협산간예치료대H형노년고혈압환자동형반광안산（Hcy）수평화심혈관사건（MACE）발생풍험적영향。방법：선취200례노년H형고혈압환자작위연구대상，장기수궤분위관찰조화대조조，매조각100례，대조조환자급여상규강압치료，관찰조환자재상규강압치료적기출상가용협산간예치료。대량조환자치료전、후적혈장Hcy수평진행검측화비교；수방량조환자，대량조환자수방기내MACE발생정황진행관찰화비교。결과：관찰조환자치료후적혈장Hcy수평교치료전현저하강，기치료후적혈장Hcy수평현저저우대조조，MACE총발생솔화뇌졸중발병솔현저저우대조조，환자발생MACE여병정（OR=1.438）、치료전혈장Hcy수평（OR=2.034）화치료후혈장Hcy수평（OR=2.869）구유상관성。결론：침대노년H형고혈압환자，재상규강압치료적동시응용협산간예치료，가현저강저환자적혈장Hcy수평화MACE발생풍험，유조우개선환자적예후。
ObjectiveTo observe and analyze the effects of folic acid treatment on homocysteine (Hcy) level and the risk of cardiovascular events (MACE) in elderly patients with H type hypertension.Methods200 cases of elderly patients with H type hypertension were selected as the research objects and randomly divided into the observation group and the control group. 100 cases were included into each group. The patients in the control group were treated with conventional antihypertensive therapy, while the patients in the observation group were treated with combined folic acid intervention on the basis of conventional anti-hypertensive therapy. The plasma Hcy levels of the patients in the two groups before and after the treatment were detected and compared. The patients in the two groups were folowed up and the occurrence of MACE of the patients in the two groups were observed and compared.Results The plasma Hcy level of the patients in the observation group after the treatment decreased significantly than that before the treatment. The plasma Hcy level after the treatment was significantly lower than that in the control group. The overal incidence of MACE and the incidence of stroke of the patients in the observation group were signifi-cantly lower than those in the control group.The occurrence of MACE of the patients was correlated with the duration of the dis-ease (OR=1.438), the plasma Hcy level after the treatment (OR=2.034) and the plasma Hcy level after the treatment (OR=2.869) .Conclusions For elderly patients with H type hypertension, the application of conventional antihypertensive therapy combined with folic acid intervention treatment can significantly reduce the plasma Hcy level and the risks of MACE of the patients, and help to improve the patient’s prognosis.
