CAJ | 학술논문

目的：探讨环氧合酶-2（COX-2）、表皮生长因子（EGFR）在结直肠癌组织中的表达及其意义。方法选取结直肠癌54例，以病灶组织为观察组，癌旁正常组织为对照组，采用免疫组织化学 Envision 方法检测 COX-2、EGFR 的表达。结果癌旁正常组织、癌组织中 COX-2的阳性表达率分别为48%、76%；EGFR 的阳性表达率分别为26%、63%。EGFR 蛋白表达与浸润深度、淋巴结转移有相关性（P <0.05）；COX-2表达与肿瘤大小、淋巴结转移存在相关性（P <0.05）。COX-2与 EGFR 之间具有相关性（r =0.375，P <0.05）。结论 COX-2、EGFR 对结直肠癌的发生、发展有协同作用，与结直肠的浸润、转移密切相关，可作为判断结直肠癌生物学行为和预后的重要参考指标。
목적：탐토배양합매-2（COX-2）、표피생장인자（EGFR）재결직장암조직중적표체급기의의。방법선취결직장암54례，이병조조직위관찰조，암방정상조직위대조조，채용면역조직화학 Envision 방법검측 COX-2、EGFR 적표체。결과암방정상조직、암조직중 COX-2적양성표체솔분별위48%、76%；EGFR 적양성표체솔분별위26%、63%。EGFR 단백표체여침윤심도、림파결전이유상관성（P <0.05）；COX-2표체여종류대소、림파결전이존재상관성（P <0.05）。COX-2여 EGFR 지간구유상관성（r =0.375，P <0.05）。결론 COX-2、EGFR 대결직장암적발생、발전유협동작용，여결직장적침윤、전이밀절상관，가작위판단결직장암생물학행위화예후적중요삼고지표。
Objective To investigate the expression of cyclooxygenase-2(COX-2)and epidermal growth factor receptor(EGFR)in colorectal cancer and its significance. Methods 54 samples of colorectal cancer were selected,and the carcinoma tissues and normal para -carcinoma tissues were defined as study and control objects,respectively. Their expression of COX-2 and EGFR were determined by immuno-histochemical method of Envision. Results In normal para-carcinoma tissues and carcinoma tissues,the positive rates of COX-2 expression were 48% and 76% ,the positive rates of EGFR expression were 26% and 63% ,respectively. The positive expression of EGFR protein was related to the depth of invasion and lymph node metastasis of colorectal cancer(P < 0. 05),and the COX-2 expression was related to the size of carcinoma and lymph node metastasis(P < 0. 05). Furthermore,there was significant correlation between expression of COX-2 and EGFR (r = 0. 375,P < 0. 05). Conclusion COX-2 and EGFR play a synergistic role in the carcinogenesis and development of colorectal cancer, which is closely related to invasion and metastasis of carcinoma tissues,and could be used as important indicators to determine the biological behavior and prognosis of colorectal cancer.