CAJ | 학술논문

目的：研究酪蛋白磷酸肽钙磷复合体（ CPP－ACP）对正畸后釉质脱矿的治疗作用。方法选择63例正畸治疗结束后，上牙（14～24，或15～25）唇面釉质存在轻度到中度脱矿的患者，随机分为2组：试验组31例，对照组32例。两组均给予含0．14％氟牙膏刷牙，每天晚上刷牙结束后试验组在脱矿牙牙面应用含有CPP－ACP的GC护牙素，对照组应用除不含CPP－ACP成分外，其他成分相同的安慰剂糊剂。临床检测指标为牙釉质脱矿指数（ EDI ）。观察时间为正畸结束当天，治疗1、3个月后，采用STATA12．0软件包对数据进行单因素方差分析。结果58例完成试验（试验组28例，对照组30例），两组EDI总和均较治疗前降低。治疗前，治疗1个月后3个月后试验组的EDI分别为（0．5903±0．2585），（0．4514±0．2077），（0．2396±0．1499）；对照组为（0．5291±0．2494），（0．4397±0．2068），（0．3287±0．1757）。治疗前和治疗1个月后两组EDI的差异无统计学意义，治疗3个月后试验组EDI少于对照组，差异有统计学意义。结论可以通过使用含CPP－ACP的GC护牙素来治疗正畸后釉质脱矿。
목적：연구락단백린산태개린복합체（ CPP－ACP）대정기후유질탈광적치료작용。방법선택63례정기치료결속후，상아（14～24，혹15～25）진면유질존재경도도중도탈광적환자，수궤분위2조：시험조31례，대조조32례。량조균급여함0．14％불아고쇄아，매천만상쇄아결속후시험조재탈광아아면응용함유CPP－ACP적GC호아소，대조조응용제불함CPP－ACP성분외，기타성분상동적안위제호제。림상검측지표위아유질탈광지수（ EDI ）。관찰시간위정기결속당천，치료1、3개월후，채용STATA12．0연건포대수거진행단인소방차분석。결과58례완성시험（시험조28례，대조조30례），량조EDI총화균교치료전강저。치료전，치료1개월후3개월후시험조적EDI분별위（0．5903±0．2585），（0．4514±0．2077），（0．2396±0．1499）；대조조위（0．5291±0．2494），（0．4397±0．2068），（0．3287±0．1757）。치료전화치료1개월후량조EDI적차이무통계학의의，치료3개월후시험조EDI소우대조조，차이유통계학의의。결론가이통과사용함CPP－ACP적GC호아소래치료정기후유질탈광。
Objective To assess the effectiveness of a ACP-CPP containing new product in reducing enamel demineralizationon post -orthodontic patients .Methods The study design was double-blind,randomized clinical trial .63 subjects with enamel decalcification (not cavitated)on their upper teeth(14~24,or 15~25)were selected and randomly divided into two groups:the experimental group (31 cases)and the control group (32 cases).The experimental group used GC Mousse while control group used placebo mousse (with-out CCP-ACP) once a day at night after brushing with fluoride dentifrice .The Enamel Decalcification Index ( EDI) was used to determine the extent/severity of white enamel demineralizationat baseline ,1 month and 3 months after treatment .A one-way analysis of variance (ANOVA)was done with STATA 12.0 software packagefor the average enamel decalcification index scores .Results 58 subjects com-pleted the trial,with 28 in the experimental group and 30 in the control group.Baseline,1 month,3 months EDI of the experimental group were(0.5903 ±0.2585),(0.4514 ±0.2077),(0.2396 ±0.1499),respectively;and those for the control group were (0.5291 ±0.2494),(0.4397 ±0.2068),(0.3287 ±0.1757),respectively.The difference between the experimental group and control group was statistically significant 3 months after treatment .Conclusions The application of CPP-ACP can help reducing the number/extent of white spot lesions already present after fixed orthodontic treatment .