CAJ | 학술논문

目的：了解小儿肾小球疾病病理与临床分布特点。方法收集353例肾活检患儿资料进行回顾性分析。结果353例患儿中诊断为紫癜性肾炎117例（33.1%），孤立性血尿94例（26.6%），原发性肾病综合征87例（24.6%），急性肾炎综合征23例（6.5%），其次还有乙肝相关性肾炎、狼疮性肾炎、孤立性蛋白尿、慢性肾炎等。肾小球疾病中以原发性肾小球疾病最为常见（206例，占58.4%），病理改变主要为：系膜增生性肾小球肾炎（MsPGN）66例，占32.0%；IgA 肾病（IgA N）54例，占26.2%；轻微病变37例，占18.0%；其他还包括微小病变（MCD）、膜增生性肾小球肾炎（MPGN）、膜性肾病（MN）、毛细血管增生性肾小球肾炎等。继发性肾小球疾病以紫癜性肾炎最常见。结论肾小球疾病以原发性肾小球疾病为主，临床诊断以孤立性血尿最常见，继发性肾炎以紫癜性肾炎最常见。
목적：료해소인신소구질병병리여림상분포특점。방법수집353례신활검환인자료진행회고성분석。결과353례환인중진단위자전성신염117례（33.1%），고립성혈뇨94례（26.6%），원발성신병종합정87례（24.6%），급성신염종합정23례（6.5%），기차환유을간상관성신염、랑창성신염、고립성단백뇨、만성신염등。신소구질병중이원발성신소구질병최위상견（206례，점58.4%），병리개변주요위：계막증생성신소구신염（MsPGN）66례，점32.0%；IgA 신병（IgA N）54례，점26.2%；경미병변37례，점18.0%；기타환포괄미소병변（MCD）、막증생성신소구신염（MPGN）、막성신병（MN）、모세혈관증생성신소구신염등。계발성신소구질병이자전성신염최상견。결론신소구질병이원발성신소구질병위주，림상진단이고립성혈뇨최상견，계발성신염이자전성신염최상견。
Objective To explore the pathological and clinical features of glomerular diseases in children. Methods The pathologi-cal data of 353 children with biopsy - proven glomerular diseases were retrospectively analyzed. Results 353 cases of children were separately diagnosed with Henoch-Schonlein purpura nephritis(117 cases,accounting for 33. 1% ),isolated hematuria(94 cases,26. 6% ),primary nephrotic syndrome(87 cases,24. 6% ),acute nephritis syndrome(23 cases,6. 5% ),followed by hepatitis B-related nephritis,lupus ne-phritis,isolated proteinuria,chronic nephritis,etc. The primary glomerular disease was the most common glomerular diseases(206 cases, 58. 4% ),its pathological changes mainly manifested as mesangial proliferative glomerulonephritis(75 cases,34. 9% ),IgA nephropathy (54 cases,25. 1% )and glomerular minor lesion(37 cases,17. 2% ),and the others included minimal change disease,membrane prolifer-ative glomerulonephritis,membranous nephropathy,capillaries proliferative glomerulonephritis,etc. The most common secondary glomerular disease was Henoch-Schonlein purpura nephritis. Conclusion Primary glomerular diseases are most common in infantile glomerular disea-ses,with main clinical diagnosis of isolated hematuria,and the most common secondary glomerulonephritis is Henoch - Schonlein purpura ne-phritis.