CAJ | 학술논문

目的：：检测 Oct4蛋白在肝细胞癌组织中的表达，并探讨其与临床病理因素的相关性。方法：收集60例病人手术切除的肝细胞癌组织及对应的癌旁组织标本，应用免疫组织化学方法检测 Oct4蛋白的表达。结果：肝细胞癌组织 Oct4蛋白阳性表达率显著高于癌旁组织(81.67% vs.15.0%)(P <0.05)；肝细胞癌组织中 Oct4蛋白的表达与肿瘤大小、血管侵犯及 TNM 分期有关(P <0.05)。结论：Oct4蛋白在肝细胞癌的发生发展中发挥重要作用，可作为判断预后有价值的分子标记物。
목적：：검측 Oct4단백재간세포암조직중적표체，병탐토기여림상병리인소적상관성。방법：수집60례병인수술절제적간세포암조직급대응적암방조직표본，응용면역조직화학방법검측 Oct4단백적표체。결과：간세포암조직 Oct4단백양성표체솔현저고우암방조직(81.67% vs.15.0%)(P <0.05)；간세포암조직중 Oct4단백적표체여종류대소、혈관침범급 TNM 분기유관(P <0.05)。결론：Oct4단백재간세포암적발생발전중발휘중요작용，가작위판단예후유개치적분자표기물。
Objective:To study the expression of Oct4 protein in hepatocellular carcinoma tissues,and discuss the correlation with clinical pathologic factors.Methods:Collected 60 cases of patients with surgical resection of hepatocellular carcinoma tissues and the corresponding tissues adjacent to carcinoma as specimens,immnohisochemical technique was used to detect the expression of Oct4 protein.Results:The positive expression rate of Oct4 protein was higher in hepatocellular carcinoma than that in the tumor adjacent tissues (75.9% vs 33.3%) (P <0.05),which was positively correlated with tumor size and closely related to its vascular invasion and TNM satage (P < 0.05 ).Conclusion:Oct4 protein is associated with tumor differentiation in hepatocellular carcinoma and may be taken as a valuable molecular marker in predicting the prognosis of hepatocellular carcinoma.