CAJ | 학술논문

目的：分析癫痫患儿血丙戊酸（VPA）水平，为临床用药提供依据。方法：服用 VPA 治疗的癫痫患儿437例，采用均相酶放大免疫检测技术（EMIT）监测血 VPA 浓度，分析年龄、性别等因素对血 VPA 浓度的影响以及血 VPA 浓度与疗效之间的关系。结果：359例（82.2%）患儿血 VPA 浓度在有效浓度范围内（50～100μg/mL）；51例（11.7％）＜50μg/mL；27例（6.2%）＞100μg/mL。年龄、性别对血 VPA 浓度的影响无统计学差异(均 P>0.05)，血 VPA 50～100μg/mL 组的疗效与<50μg/mL 组比较，有统计学差异(χ2=55.10，P<0.05)。结论：癫痫患儿血 VPA 水平对临床用药具有重要参考意义。
목적：분석전간환인혈병무산（VPA）수평，위림상용약제공의거。방법：복용 VPA 치료적전간환인437례，채용균상매방대면역검측기술（EMIT）감측혈 VPA 농도，분석년령、성별등인소대혈 VPA 농도적영향이급혈 VPA 농도여료효지간적관계。결과：359례（82.2%）환인혈 VPA 농도재유효농도범위내（50～100μg/mL）；51례（11.7％）＜50μg/mL；27례（6.2%）＞100μg/mL。년령、성별대혈 VPA 농도적영향무통계학차이(균 P>0.05)，혈 VPA 50～100μg/mL 조적료효여<50μg/mL 조비교，유통계학차이(χ2=55.10，P<0.05)。결론：전간환인혈 VPA 수평대림상용약구유중요삼고의의。
Objective:To provide references for clinical drug administration by analyzing the serum concentrations of valproic acid (VPA) in pediatric epilepsy. Methods: Enyme-mutiplied immunoassay technique (EMIT) was used to detect the serum concentrations of VPA in 437 pediatric epilepsy patients. The impact of age and sex on the serum concentrations of VPA and the relation between the serum concentrations of VPA and therapeutic effect were analyzed. Results: Among the serum concentrations of VPA in 437 cases, 51 cases(11.7%) were lower than 50μg/mL; 359 cases(82.2%) between 50 and 100 μg/mL; 27 cases( 6.2%) higher than 100 μg/mL. The impact of age and sex on the serum concentrations of VPA had no statistical difference (P>0.05), while the therapeutic effect be-tween 50~100 μg/mL group and <50 μg/mL group had statistical difference (χ2=55.10, P<0.05). Conclusion: The monitoring of VPA will be great important reference to drug administration for pediatric epilepsy patients.