中国骨科临床与基础研究杂志
中國骨科臨床與基礎研究雜誌
중국골과림상여기출연구잡지
Chinese Journal of Clinical and Basic Orthopaedic Research
2015年
5期
275-280
,共6页
关节成形术,置换,髋%降钙素原%骨形态发生蛋白质类%关节功能%康复
關節成形術,置換,髖%降鈣素原%骨形態髮生蛋白質類%關節功能%康複
관절성형술,치환,관%강개소원%골형태발생단백질류%관절공능%강복
Arthroplasty,replacement,hip%Procalcitonin%Bone morphogenetic proteins%Joint function%Rehabilitation
目的 探讨髋关节置换围术期血清降钙素原(PCT)和骨形态发生蛋白2(BMP2)水平与术后髋关节功能恢复的关系.方法随机选取2013年1月至2014年10月在普宁市人民医院行髋关节置换术的148例股骨颈骨折患者作为观察组,另选取30例同期健康体检者作为对照组.采用酶联免疫吸附法(ELISA)检测两组术前,术后1、3、5、7、14 d血清PCT和BMP2水平;术后1、3、6个月按Harris评分评价观察组髋关节功能恢复情况;采用Pearson相关性分析评估患者围术期血清PCT和BMP2水平与术后髋关节功能恢复的关系.结果 观察组术前,术后1、3、5、7、14 d血清PCT和BMP2水平均高于对照组(P<0.05).观察组术后3、5、7、14 d血清PCT和BMP2水平均较术前降低(P<0.05).术后6个月髋关节功能优、良、可、差分别为69、51、22、6例.髋关节功能优良者手术前后各时相点血清PCT水平均较髋关节功能中差者低,而血清BMP2水平则较高(P<0.05);术后髋关节功能与围术期血清PCT水平呈负相关(P<0.05),与血清BMP2水平呈正相关(P<0.05).结论 血清PCT和BMP2水平可作为评价髋关节置换术后患者髋关节功能恢复的参考指标,围术期血清PCT水平较高而BMP2水平较低者术后髋关节功能恢复较差.
目的 探討髖關節置換圍術期血清降鈣素原(PCT)和骨形態髮生蛋白2(BMP2)水平與術後髖關節功能恢複的關繫.方法隨機選取2013年1月至2014年10月在普寧市人民醫院行髖關節置換術的148例股骨頸骨摺患者作為觀察組,另選取30例同期健康體檢者作為對照組.採用酶聯免疫吸附法(ELISA)檢測兩組術前,術後1、3、5、7、14 d血清PCT和BMP2水平;術後1、3、6箇月按Harris評分評價觀察組髖關節功能恢複情況;採用Pearson相關性分析評估患者圍術期血清PCT和BMP2水平與術後髖關節功能恢複的關繫.結果 觀察組術前,術後1、3、5、7、14 d血清PCT和BMP2水平均高于對照組(P<0.05).觀察組術後3、5、7、14 d血清PCT和BMP2水平均較術前降低(P<0.05).術後6箇月髖關節功能優、良、可、差分彆為69、51、22、6例.髖關節功能優良者手術前後各時相點血清PCT水平均較髖關節功能中差者低,而血清BMP2水平則較高(P<0.05);術後髖關節功能與圍術期血清PCT水平呈負相關(P<0.05),與血清BMP2水平呈正相關(P<0.05).結論 血清PCT和BMP2水平可作為評價髖關節置換術後患者髖關節功能恢複的參攷指標,圍術期血清PCT水平較高而BMP2水平較低者術後髖關節功能恢複較差.
목적 탐토관관절치환위술기혈청강개소원(PCT)화골형태발생단백2(BMP2)수평여술후관관절공능회복적관계.방법수궤선취2013년1월지2014년10월재보저시인민의원행관관절치환술적148례고골경골절환자작위관찰조,령선취30례동기건강체검자작위대조조.채용매련면역흡부법(ELISA)검측량조술전,술후1、3、5、7、14 d혈청PCT화BMP2수평;술후1、3、6개월안Harris평분평개관찰조관관절공능회복정황;채용Pearson상관성분석평고환자위술기혈청PCT화BMP2수평여술후관관절공능회복적관계.결과 관찰조술전,술후1、3、5、7、14 d혈청PCT화BMP2수평균고우대조조(P<0.05).관찰조술후3、5、7、14 d혈청PCT화BMP2수평균교술전강저(P<0.05).술후6개월관관절공능우、량、가、차분별위69、51、22、6례.관관절공능우량자수술전후각시상점혈청PCT수평균교관관절공능중차자저,이혈청BMP2수평칙교고(P<0.05);술후관관절공능여위술기혈청PCT수평정부상관(P<0.05),여혈청BMP2수평정정상관(P<0.05).결론 혈청PCT화BMP2수평가작위평개관관절치환술후환자관관절공능회복적삼고지표,위술기혈청PCT수평교고이BMP2수평교저자술후관관절공능회복교차.
Objective To investigate the relationship between perioperative serum procalcitonin (PCT),bone morphogenetic protein 2 (BMP2) and postoperative recovery of hip function for patients with hip replacement.Methods A total of 148 patients with femoral neck fractures who underwent hip replacement from January 2013 to October 2014 in Puning People's Hospital,were randomly selected as the observation group,and 30 healthy who underwent physical examination during the same period were selected as the control group.The serum levels of PCT and BMP2 were detected by enzyme-linked immunosorbent assay (ELISA) before the operation and 1,3,5,7,14 days after the operation.Recovery of hip function was evaluated by Harris hip score at 1,3,6 months postoperatively.Pearson correlation analysis was applied to analyze the relationship between perioperative serum PCT,BMP2 levels and postoperative recovery of hip joint function.Results The levels of serum PCT and BMP2 in the observation group were higher than those in the control group at the different time-points (P <0.05).In observation group,preoperative serum levels of PCT and BMP2 were higher than those at 3,5,7 and 14 d postoperatively (P <0.05).Harris hip score after 6 months was as follows: 69 excellent,51 good,22 fair and 6 poor.The levels of serum PCT in the patients who evaluated as good and excellent hip function were lower,while levels of BMP2 were higher when compared with the patients with fair or poor hip function (P <0.05); Postoperative function of hip joint was negatively correlated with serum PCT levels,while was positively correlated with serum BMP2 levels (P <0.05).Conclusion For patients with hip replacement,serum PCT,BMP2 levels can be used as reference indexes to evaluate the recovery of hip function,which patients with high serum PCT and low serum BMP2 may show poor hip function recovery.
