CAJ | 학술논문

目的：探讨 Th1／Th2平衡在复发性阿弗他溃疡（RAU）免疫发病机制中的作用及意义。方法：RAU 患者35例（轻型25例，重型10例）及健康对照24例，采用流式细胞术（CBA）检测患者溃疡期血清中 Th1类细胞因子（IFN-γ、TNF-α、IL-2）及Th2类细胞因子（IL-4、IL-6、IL-10）的表达水平，分析其与 RAU 临床特征的关系。结果：在轻型 RAU 患者中，IL-4、IL-10表达水平明显高于正常组（P ＜0．05）；在重型 RAU 患者中，IFN-γ、IL-4、IL-10表达水平明显高于正常组（P ＜0．05）；重型 RAU 患者 IFN-γ、IL-10表达水平明显高于轻型组（P ＜0．05）；IFN-γ、IL-4、IL-10表达水平与 RAU 病情严重程度正相关（P ＜0．05）。结论：RAU 患者表现为 Th2细胞占优势的免疫应答；其中，IFN-γ、IL-4、IL-10表达水平与 RAU 病情严重程度有关。
목적：탐토 Th1／Th2평형재복발성아불타궤양（RAU）면역발병궤제중적작용급의의。방법：RAU 환자35례（경형25례，중형10례）급건강대조24례，채용류식세포술（CBA）검측환자궤양기혈청중 Th1류세포인자（IFN-γ、TNF-α、IL-2）급Th2류세포인자（IL-4、IL-6、IL-10）적표체수평，분석기여 RAU 림상특정적관계。결과：재경형 RAU 환자중，IL-4、IL-10표체수평명현고우정상조（P ＜0．05）；재중형 RAU 환자중，IFN-γ、IL-4、IL-10표체수평명현고우정상조（P ＜0．05）；중형 RAU 환자 IFN-γ、IL-10표체수평명현고우경형조（P ＜0．05）；IFN-γ、IL-4、IL-10표체수평여 RAU 병정엄중정도정상관（P ＜0．05）。결론：RAU 환자표현위 Th2세포점우세적면역응답；기중，IFN-γ、IL-4、IL-10표체수평여 RAU 병정엄중정도유관。
Objective:To explore the possible role and clinical significance of Th1 and Th2 class cytokines in the pathogenesis of re-current aphthous ulcer (RAU).Methods:35 cases with RAU,25 of minor RAU(MiRAU)and 1 0 of major RAU(MaRAU),were enrolled and 24 healthy subjects served as the controls.The expression levels of Th1 type cytokines (IFN-γ,TNF-α,IL-2)and Th2 type cytokines (IL-4,IL-6,IL-1 0)in the serum of peripheral blood were investigated by flow cytometry CBA methods and their rela-tionship with the clinical features of RAU was analyzed by SPSS 1 1 .5.Results:The expression level of IL-4 and IL-1 0 in MiRAU group was higher than that in the controls(P <0.05),and the expression level of IFN-γ,IL-4 and IL-1 0 in MaRAU group was higher than that in the controls(P <0.05).The expression level of IFN-γand IL-1 0 in MaRAU was higher than that in MiRAU.There was a positive correlation between the levels of IFN-γ,IL-4,IL-1 0 and the severity of RAU.Conclusion:Predominant Th2 immune re-sponse plays a role in RAU,and the level of IFN-γ,IL-4 and IL-1 0 is correlated with the severity of RAU.