临床外科杂志
臨床外科雜誌
림상외과잡지
Journal of Clinical Surgery
2015年
11期
824-826
,共3页
乳腺癌%血管生成素样蛋白 2%诊断%预后
乳腺癌%血管生成素樣蛋白 2%診斷%預後
유선암%혈관생성소양단백 2%진단%예후
breast cancer%angiopoietin-like protein 2%diagnosis%prognosis
目的：分析血管生成素样蛋白2（angiopoietin-like protein 2，Angptl2）在乳腺癌组织和血清中的表达。方法乳腺癌和癌旁组织蜡块78例，免疫组化法检测患者术前与术后血清Angptl2蛋白的表达，酶联免疫吸附试验法（ELISA）检测患者血清 Angptl2水平，并分析 Angptl2蛋白的表达与临床病理特征及无进展生存（ progression-free survival，PFS）的关系。受试者特征（ the receiver operating characteristics，ROC）曲线分析血清 Angptl2诊断乳腺癌的敏感性与特异性。结果乳腺癌组织标本中，Angptl2表达阳性64例（82.1％），其中，Angptl2高/中表达在癌组织和癌旁组织分别为42例（53.8％）和6例（7.7％）（P ﹤0.01）。Angptl2高/中表达与患者淋巴结转移有关，并导致 PFS 缩短。乳腺癌患者血清中 Angptl2水平为（218.72±88.02）ng/ ml，对照组为（80.88±30.59）ng/ ml，两组比较差异有统计学意义（P ﹤0.01）。曲线下面积（area under the curve，AUC）为0.909，诊断效能良好。术后1周 Angptl2水平下降至（142.43±60.29）ng/ ml，但仍高于对照组，较差异有统计学意义（P ﹤0.01）。结论乳腺癌患者癌组织和血清中 Angptl2表达均升高，Angptl2可作为乳腺癌早期诊断与预后判断的标志物。
目的：分析血管生成素樣蛋白2（angiopoietin-like protein 2，Angptl2）在乳腺癌組織和血清中的錶達。方法乳腺癌和癌徬組織蠟塊78例，免疫組化法檢測患者術前與術後血清Angptl2蛋白的錶達，酶聯免疫吸附試驗法（ELISA）檢測患者血清 Angptl2水平，併分析 Angptl2蛋白的錶達與臨床病理特徵及無進展生存（ progression-free survival，PFS）的關繫。受試者特徵（ the receiver operating characteristics，ROC）麯線分析血清 Angptl2診斷乳腺癌的敏感性與特異性。結果乳腺癌組織標本中，Angptl2錶達暘性64例（82.1％），其中，Angptl2高/中錶達在癌組織和癌徬組織分彆為42例（53.8％）和6例（7.7％）（P ﹤0.01）。Angptl2高/中錶達與患者淋巴結轉移有關，併導緻 PFS 縮短。乳腺癌患者血清中 Angptl2水平為（218.72±88.02）ng/ ml，對照組為（80.88±30.59）ng/ ml，兩組比較差異有統計學意義（P ﹤0.01）。麯線下麵積（area under the curve，AUC）為0.909，診斷效能良好。術後1週 Angptl2水平下降至（142.43±60.29）ng/ ml，但仍高于對照組，較差異有統計學意義（P ﹤0.01）。結論乳腺癌患者癌組織和血清中 Angptl2錶達均升高，Angptl2可作為乳腺癌早期診斷與預後判斷的標誌物。
목적：분석혈관생성소양단백2（angiopoietin-like protein 2，Angptl2）재유선암조직화혈청중적표체。방법유선암화암방조직사괴78례，면역조화법검측환자술전여술후혈청Angptl2단백적표체，매련면역흡부시험법（ELISA）검측환자혈청 Angptl2수평，병분석 Angptl2단백적표체여림상병리특정급무진전생존（ progression-free survival，PFS）적관계。수시자특정（ the receiver operating characteristics，ROC）곡선분석혈청 Angptl2진단유선암적민감성여특이성。결과유선암조직표본중，Angptl2표체양성64례（82.1％），기중，Angptl2고/중표체재암조직화암방조직분별위42례（53.8％）화6례（7.7％）（P ﹤0.01）。Angptl2고/중표체여환자림파결전이유관，병도치 PFS 축단。유선암환자혈청중 Angptl2수평위（218.72±88.02）ng/ ml，대조조위（80.88±30.59）ng/ ml，량조비교차이유통계학의의（P ﹤0.01）。곡선하면적（area under the curve，AUC）위0.909，진단효능량호。술후1주 Angptl2수평하강지（142.43±60.29）ng/ ml，단잉고우대조조，교차이유통계학의의（P ﹤0.01）。결론유선암환자암조직화혈청중 Angptl2표체균승고，Angptl2가작위유선암조기진단여예후판단적표지물。
Objective To explore Angptl2(angiopoietin-like protein 2)expression in tumor tis-sue and serum in patients with breast cancer(BC). Methods A total of 78 BC patients were enrolled in this study. Immunohistochemistry was used to detect Angptl2 expression in tumor and adjacent normal tis-sues. Preoperative and postoperative serum Angptl2 levels were determined via ELISA. Correlation among Angptl2 expression,clinicopathological factors and progression-free survival(PFS)were further evalua-ted. The receiver operating characteristics(ROC)curve was constructed to describe diagnostic specificity and sensitivity. Results Angptl2 was positively expressed in 64(82. 1% )cases. The rates of high and moderate expression of Angpt l2 in tumor and adjacent tissues were 53. 8%(42 / 78)and 7. 7%(6 / 78), respectively(P ﹤ 0. 001). Moreover,the elevated Angptl2 protein was significantly associated with lymph metastasis and adverse PFS. In addition,serum Angptl2 level in BC patients was significantly higher than that in benign controls[(218. 72 ± 88. 02)vs(80. 88 ± 30. 59)ng/ ml,P ﹤ 0. 01]. The area under the curve(AUC)was 0. 909,which indicated a good function for diagnosis. Postoperative serum Angptl2 level was decreased to(142. 43 ± 60. 29)ng/ ml,but still higher than that in controls(P ﹤ 0. 01). Conclusion The expression of Angptl2 may increase in tumor tissue and serum of BC and it may be a potential tumor marker for diagnosis and prognosis.
