CAJ | 학술논문

目的：探讨 Th 亚群以及 IL-17在牙周炎发病中的作用。方法：用流式细胞术检测健康对照10例，慢性牙周炎（CP）11例，侵袭性牙周炎（AgP）8例患者外周血中辅助性 T 细胞亚群 Th1、Th2、Th17的水平，ELISA 法检测龈沟液（GCF）中 IL-17的水平。结果：与正常对照组相比2组牙周炎患者外周血中 Th1、Th17所占比例明显升高（P ＜0．01），Th2比例明显降低（P ＜0．01）；龈沟液内 IL-17浓度明显升高（P ＜0．01）。CP 组 IL-17浓度与 PD 和 AL 正相关（P ＝0．000），AgP 组 IL-17与 PD 正相关（P ＝0．007）。结论：牙周炎患者机体免疫功能降低，龈沟液中 IL-17升高与牙周炎发生发展有关。
목적：탐토 Th 아군이급 IL-17재아주염발병중적작용。방법：용류식세포술검측건강대조10례，만성아주염（CP）11례，침습성아주염（AgP）8례환자외주혈중보조성 T 세포아군 Th1、Th2、Th17적수평，ELISA 법검측간구액（GCF）중 IL-17적수평。결과：여정상대조조상비2조아주염환자외주혈중 Th1、Th17소점비례명현승고（P ＜0．01），Th2비례명현강저（P ＜0．01）；간구액내 IL-17농도명현승고（P ＜0．01）。CP 조 IL-17농도여 PD 화 AL 정상관（P ＝0．000），AgP 조 IL-17여 PD 정상관（P ＝0．007）。결론：아주염환자궤체면역공능강저，간구액중 IL-17승고여아주염발생발전유관。
Objective:To study the correlation of Th subsets in peripheral blood(PB)and IL-1 7 in gingival crevicular fluid(GCF)in the patients with periodontitis.Methods:1 0 healthy controls,1 1 cases with chronic periodontitis(CP)and 8 cases with aggressive pe-riodontitis(AgP)were included.Th1 ,Th2 and Th1 7 in PB were measured by flowcytometry,IL-1 7 in GCF was examined by ELISA. Periodental indexes(PLI,PD,AL and BI)were measured.Results:In the CP group and the AgP group,Th1 and Th1 7 were signifi-cantly higher,Th2 was lower than those in the control group(P <0.01 )(between CP and AgP groups,P >0.05),and IL-1 7 in GCF were significantly higher(P <0.01 )(between CP and AgP groups,P >0.05).In group CP IL-1 7 leve in GCF was positively correla-ted with PD and AL(P =0.000),in group AgP with PD(P =0.007).Conclusion:Deficiency of immunologic function and increase of IL-1 7 in the GCF is related with the onset and development of periodontitis.