胃肠病学
胃腸病學
위장병학
Chinese Journal of Gastroenterology
2015年
11期
683-686
,共4页
自噬%炎症性肠病%Crohn病%结肠炎,溃疡性%发病机制%全基因组关联研究
自噬%炎癥性腸病%Crohn病%結腸炎,潰瘍性%髮病機製%全基因組關聯研究
자서%염증성장병%Crohn병%결장염,궤양성%발병궤제%전기인조관련연구
Autophagy%Inflammatory Bowel Disease%Crohn Disease%Colitis,Ulcerative%Pathogenesis%Genome-Wide Association Study
炎症性肠病( IBD)是一种慢性、非特异性肠道炎性疾病,其发病机制与环境、遗传以及免疫等多种因素相关。自噬在细胞稳态和机体免疫中发挥重要作用,自噬异常可能参与IBD的发病。全基因组关联分析( GWAS)研究证实,ATG16L1、IRGM、NOD2等自噬相关基因与IBD密切相关。本文就自噬异常在IBD发病机制中的作用作一综述。
炎癥性腸病( IBD)是一種慢性、非特異性腸道炎性疾病,其髮病機製與環境、遺傳以及免疫等多種因素相關。自噬在細胞穩態和機體免疫中髮揮重要作用,自噬異常可能參與IBD的髮病。全基因組關聯分析( GWAS)研究證實,ATG16L1、IRGM、NOD2等自噬相關基因與IBD密切相關。本文就自噬異常在IBD髮病機製中的作用作一綜述。
염증성장병( IBD)시일충만성、비특이성장도염성질병,기발병궤제여배경、유전이급면역등다충인소상관。자서재세포은태화궤체면역중발휘중요작용,자서이상가능삼여IBD적발병。전기인조관련분석( GWAS)연구증실,ATG16L1、IRGM、NOD2등자서상관기인여IBD밀절상관。본문취자서이상재IBD발병궤제중적작용작일종술。
Inflammatory bowel disease( IBD)is a chronic and nonspecific intestinal inflammatory disease caused by multiple factors such as environment,genetic susceptibility and immune disturbance. Autophagy plays an important role in cellular homeostasis and immune. Autophagy abnormalities may be involved in the pathogenesis of IBD. Genome-wide association studies(GWAS)have provided compelling evidence that autophagy related genes,including ATG16L1,IRGM and NOD2,are significantly associated with IBD. This article reviewed the abnormal autophagy in pathogenesis of IBD.