CAJ | 학술논문

目的：评价 NaHCO3促凝氧化硅凝胶的动物活体毒性。方法：根据 YY／T 0244-1996标准，对受试样本进行 SD 大鼠经口途径短期全身毒性试验评价；根据 T16886．10-2005／ISO 10993-10：2002标准，对受试样本进行白色豚鼠刺激与迟发型超敏反应试验评价；根据 YY／T 0127．13-2009标准，对受试样本进行金黄地鼠口腔黏膜刺激试验评价。结果：经口途径短期全身毒性试验中，试验组与对照组大鼠食物利用率差小于对照组食物利用率的20％；试验组与对照组的体重相对增长率无差异；试验组大鼠在试验期间未观察到明显毒性体征。刺激与迟发型超敏反应试验中，试验组和对照组豚鼠在激发接触后24 h和48 h 皮肤均未见红斑及水肿，致敏率为0％。口腔黏膜刺激试验中，肉眼观察和组织病理学观察结果均显示对试验组与对照组金黄地鼠的口腔黏膜的刺激指数为0。结论：NaHCO3促凝的氧化硅凝胶对活体动物不具有明显毒性。
목적：평개 NaHCO3촉응양화규응효적동물활체독성。방법：근거 YY／T 0244-1996표준，대수시양본진행 SD 대서경구도경단기전신독성시험평개；근거 T16886．10-2005／ISO 10993-10：2002표준，대수시양본진행백색돈서자격여지발형초민반응시험평개；근거 YY／T 0127．13-2009표준，대수시양본진행금황지서구강점막자격시험평개。결과：경구도경단기전신독성시험중，시험조여대조조대서식물이용솔차소우대조조식물이용솔적20％；시험조여대조조적체중상대증장솔무차이；시험조대서재시험기간미관찰도명현독성체정。자격여지발형초민반응시험중，시험조화대조조돈서재격발접촉후24 h화48 h 피부균미견홍반급수종，치민솔위0％。구강점막자격시험중，육안관찰화조직병이학관찰결과균현시대시험조여대조조금황지서적구강점막적자격지수위0。결론：NaHCO3촉응적양화규응효대활체동물불구유명현독성。
Objective:To evaluate the toxicity of NaHCO3 coagulated silica gel for coating on the zirconia bonding surface in vivo. Methods:The silica gel was subjected to short term systemic toxicity test by delayed-type hypersensitivity test by oral route and oral mucosa irritation test according to the YY/T 0244-1 996 standards,T1 6886.1 0-2005 /ISO 1 0993-1 0:2002 standards and YY/T 01 27. 1 3-2009 standards respectively.Results:In the short term systemic acute toxicity tested mice there was no significant difference in the weekly food utilization rate and relative body weight growth rate between the experimental and control groups.No abnormality and path-ological change were observed.The delayed-type hypersensitivity test showed that no erythema and edema reaction presented in all the test cavies after 24 and 48 h of stimulation contact,and the sensitization rate was 0.There was no local or systemic pathological change in all the oral mucosa irritation test animals.Conclusion:NaHCO3 procoagulant silica gel has no in vivo toxicity.