CAJ | 학술논문

胆道闭锁是一种婴幼儿肝内外胆管阻塞和肝脏进行性纤维化的疾病，病因和发病机制尚不明确，若不加以干预，多数患儿于1岁左右死亡。本文回顾了近年来新生儿及动物模型中胆道闭锁肝纤维化研究进展，提出了尚未解决的问题和今后的研究方向。
담도폐쇄시일충영유인간내외담관조새화간장진행성섬유화적질병，병인화발병궤제상불명학，약불가이간예，다수환인우1세좌우사망。본문회고료근년래신생인급동물모형중담도폐쇄간섬유화연구진전，제출료상미해결적문제화금후적연구방향。
Biliary atresia is an infant disease characterized by obstruction of the internal and ex-ternal bile duct and progressive fibrosing process of the liver. Its etiology and pathogenesis remains un-clear and most infants would die in one year if thereˊs no medical intervention. In this article,we reviewed recent research progress of liver fibrosis in biliary atresia in infants and animal models,which proposed some unsettled problems and research direction in the future.