CAJ | 학술논문

目的探讨PTEN表达对妊娠期糖尿病患者的临床意义. 方法选取2014年1月至2015年6月在我院就诊的妊娠期糖尿病患者60例, 根据血糖和糖化血红蛋白水平分为血糖控制良好组和血糖控制不良组, 每组各30例, 另选同期在我院正常分娩的孕妇30例作为正常组. 使用免疫组织化学的方法检测各组的胎盘组织中PTEN的表达水平并进行分析. 结果 PTEN阳性表达于胎盘血管内皮细胞, 绒毛间质细胞和合体滋养层细胞几乎无PTEN表达阳性反应; 血糖控制不良组、血糖控制良好组、正常组的PTEN表达依次升高, 组间两两比较, P<0.05, 差异具有统计学意义. 结论妊娠期糖尿病存在不同程度的PTEN表达水平降低, PTEN可能在妊娠期糖尿病的病理过程中发挥作用.
목적 탐토PTEN표체대임신기당뇨병환자적림상의의. 방법 선취2014년1월지2015년6월재아원취진적임신기당뇨병환자60례, 근거혈당화당화혈홍단백수평분위혈당공제량호조화혈당공제불량조, 매조각30례, 령선동기재아원정상분면적잉부30례작위정상조. 사용면역조직화학적방법검측각조적태반조직중PTEN적표체수평병진행분석. 결과 PTEN양성표체우태반혈관내피세포, 융모간질세포화합체자양층세포궤호무PTEN표체양성반응; 혈당공제불량조、 혈당공제량호조、 정상조적PTEN표체의차승고, 조간량량비교, P<0.05, 차이구유통계학의의. 결론 임신기당뇨병존재불동정도적PTEN표체수평강저, PTEN가능재임신기당뇨병적병리과정중발휘작용.
Objective To explore the significance of PTEN expression in patients with gestational diabetes mellitus. Methods 60 patients who suffered from the gestational diabetes mellitus were selected and divided into good blood glucose control group and poor blood glucose control group, with 30 patients in each group. 30 normal pregnant women in our hospital at the same period were selected as normal group. The expression levels of PTEN in placenta tissues of 3 groups were detected by immunohistochemistry. Results The expression of PTEN was in placental vascular endothelial cells, while villous stromal cells and syncytiotrophoblast had almost no PTEN positive reaction. The expression of PTEN in the poor blood glucose control group, good blood glucose control group and normal group increased in turn, with statistically significant difference (P<0.05). Conclusions PTEN is decreasingly expressed in gestational diabetes mellitus, which may play a role in the pathological process of gestational diabetes mellitus.