CAJ | 학술논문

为了探讨束缚应激对小鼠神经递质、行为的影响及有氧运动的干预效果。选用1月龄C57BL/6小鼠80只，随机分为4组：控制组(Control，n=20只)、束缚应激组(Stress，n=20只)、运动组(Ex，n=20只)、运动束缚应激组(Stress+Ex，n=20只)。控制组安静饲养，束缚应激组进行2周的束缚应激，运动组每天进行2 h跑台锻炼，运动束缚应激组同时进行束缚应激和跑台锻炼。结果发现：行为试验中，束缚应激组小鼠社交行为显著下降、焦虑及抑郁行为水平发生显著上升(P<0.05)，而运动干预能够缓解束缚应激对这些行为的影响。生化指标同样说明有氧锻炼有效缓解了束缚应激导致的行为和单胺类神经递质的改变。结果说明：束缚应激会导致社交及情绪相关行为的改变，而运动干预会起到有效的缓解作用。
위료탐토속박응격대소서신경체질、행위적영향급유양운동적간예효과。선용1월령C57BL/6소서80지，수궤분위4조：공제조(Control，n=20지)、속박응격조(Stress，n=20지)、운동조(Ex，n=20지)、운동속박응격조(Stress+Ex，n=20지)。공제조안정사양，속박응격조진행2주적속박응격，운동조매천진행2 h포태단련，운동속박응격조동시진행속박응격화포태단련。결과발현：행위시험중，속박응격조소서사교행위현저하강、초필급억욱행위수평발생현저상승(P<0.05)，이운동간예능구완해속박응격대저사행위적영향。생화지표동양설명유양단련유효완해료속박응격도치적행위화단알류신경체질적개변。결과설명：속박응격회도치사교급정서상관행위적개변，이운동간예회기도유효적완해작용。
In order to probe into the effects of restrained stress on monoamine neurotransmitters and behaviors of mice as well as aerobic exercise intervention effects, the authors selected 80 1-month old C57BL/6 mice, randomly divided them into 4 groups: a control group (Control, n=20), a restrained stress group (Stress, n=20), an exercise group (Ex, n=20) and an exercise + restrained stress group (Stress + Ex, n=20), fed the control group in a calm con-dition, let the restrained stress group suffer restrained stress for 2 weeks, let the exercise group exercise on a tread-mill 2 hours a day, let the exercise + restrained stress group suffer restrained stress and exercise on a treadmill si-multaneously, and revealed the following findings: in the behavior experiment, the mice in the restrained stress group had significantly decreased social behaviors and significantly increased levels of anxiety and depression be-haviors (P<0.05), while exercise intervention could alleviate the effects of restrained stress on these behaviors. Bio-chemical indexes indicated as well that aerobic exercise effectively alleviated retrained stress induced changes of behaviors and monoamine neurotransmitters. Conclusion: restrained stress will cause changes of social communica-tion and emotion related behaviors, while exercise intervention will play an effective role of alleviation.