贵州医药
貴州醫藥
귀주의약
Guizhou Medical Journal
2015年
11期
964-966
,共3页
张国强%刘俊%徐文科%袁靖
張國彊%劉俊%徐文科%袁靖
장국강%류준%서문과%원정
华法林%基因多态性%细胞色素P4502C9%维生素K环氧化物还原酶复合体亚单位1%个体化用药
華法林%基因多態性%細胞色素P4502C9%維生素K環氧化物還原酶複閤體亞單位1%箇體化用藥
화법림%기인다태성%세포색소P4502C9%유생소K배양화물환원매복합체아단위1%개체화용약
Warfarin%Gene polymorphism%CYP2C9%VKORC1%Individualized medication
目的:探讨CYP2C9和VKORC1基因在皖南地区汉族人群中多态性分布。方法选取皖南医学院弋矶山医院2013年8月至2014年8月135例需接受华法林抗凝治疗的患者,采用原位杂交荧光染色分析技术检测患者CYP2C91075A>C和VKORC11639G>A基因型。结果患者CYP2C91075AA基因型94.07%,AC基因型为5.19%,CC基因型为0.74%;VKORC11639基因 AA 型83.71%,GA 型14.81%,GG 型1.48%。CYP2C91075A等位基因分布频率为96.67%,C等位基因频率为3.33%;VKORC11639A等位基因和G等位基因分布频率分别为91.11%和8.89%。CYP2C91075AA/VKORC11639AA基因组合分布频率为78.52%。结论皖南地区汉族人群CYP2C9和VKORC1基因存在多态性分布,可为华法林个体化抗凝提供用药参考。
目的:探討CYP2C9和VKORC1基因在皖南地區漢族人群中多態性分佈。方法選取皖南醫學院弋磯山醫院2013年8月至2014年8月135例需接受華法林抗凝治療的患者,採用原位雜交熒光染色分析技術檢測患者CYP2C91075A>C和VKORC11639G>A基因型。結果患者CYP2C91075AA基因型94.07%,AC基因型為5.19%,CC基因型為0.74%;VKORC11639基因 AA 型83.71%,GA 型14.81%,GG 型1.48%。CYP2C91075A等位基因分佈頻率為96.67%,C等位基因頻率為3.33%;VKORC11639A等位基因和G等位基因分佈頻率分彆為91.11%和8.89%。CYP2C91075AA/VKORC11639AA基因組閤分佈頻率為78.52%。結論皖南地區漢族人群CYP2C9和VKORC1基因存在多態性分佈,可為華法林箇體化抗凝提供用藥參攷。
목적:탐토CYP2C9화VKORC1기인재환남지구한족인군중다태성분포。방법선취환남의학원익기산의원2013년8월지2014년8월135례수접수화법림항응치료적환자,채용원위잡교형광염색분석기술검측환자CYP2C91075A>C화VKORC11639G>A기인형。결과환자CYP2C91075AA기인형94.07%,AC기인형위5.19%,CC기인형위0.74%;VKORC11639기인 AA 형83.71%,GA 형14.81%,GG 형1.48%。CYP2C91075A등위기인분포빈솔위96.67%,C등위기인빈솔위3.33%;VKORC11639A등위기인화G등위기인분포빈솔분별위91.11%화8.89%。CYP2C91075AA/VKORC11639AA기인조합분포빈솔위78.52%。결론환남지구한족인군CYP2C9화VKORC1기인존재다태성분포,가위화법림개체화항응제공용약삼고。
Objective To study the genetic polymorphism of CYP2C9 and VKORC1 in Chinese Han population from South Anhui areas .Method 135 patients receiving anticoagulant therapy with warfarin in one 3rd grade class hospitals of Wannan Medical College from August 2013 to August 2014 were involved .The genotype of CYP2C9 1075A>C and VKORC1 1639G>A were detected by fluorescence in situ hybridization FISH .Result The frequen‐cies of AA ,AC and CC were 94 .07% ,5 .19% and 0 .74% separately in CYP2C9 1075A>C ,and that of VKORC1 1639AA was 83 .71% ,GA was 14 .81% and GG was 1 .48% , separately . The allelic frequencies A and C of CYP2C9 1075A> C were 96 .67% and 3 .33% and that of A and G of VKORC1 1639G/A were 91 .11% and 8 .89% ,separately .The frequency of CYP2C9 1075AA and VKORC1 1639AA combined was 78 .52% .Conclusion The CYP2C9 and VKORC1 genetic polymorphism presents in Chinese Han population from south Anhui areas , which could provide the reference on individualized anticoagulant therapy with warfarin .