临床医学工程
臨床醫學工程
림상의학공정
Clinical Medical & Engineering
2015年
11期
1420-1421
,共2页
新生儿败血症%C反应蛋白%白介素-6%降钙素原%意义
新生兒敗血癥%C反應蛋白%白介素-6%降鈣素原%意義
신생인패혈증%C반응단백%백개소-6%강개소원%의의
Neonatal sepsis%C-reactive protein (CRP)%Interleukin-6 (IL-6)%Procalcitonin (PCT)%Significance
目的 探讨联合检测血清白介素-6 (IL-6)、 降钙素原 (PCT)、 C反应蛋白 (CRP) 在新生儿败血症诊治中的价值和意义. 方法 按照随机、 双盲、 对照的原则将2012年2月至2015年2月间来我院新生儿科住院治疗的100例新生儿败血症患儿作为观察组, 抽取同一时间段来新生儿科就诊的100例非败血症患儿作为对照组, 分别检测两组患儿血清CRP、 IL-6、 PCT.结果 观察组患儿的血清CRP、 IL-6、 PCT水平显著高于对照组患儿 (P<0.05); 血清CRP、 IL-6、 PCT联合检测其灵敏度、阳性预测值、 阴性预测值和单一检测相比均显著升高 (P<0.05); 患儿CRP、 IL-6、 PCT和器官功能衰竭评估 (SOFA) 呈正相关, 而和危重评分系统 (PCIS) 评分呈负相关. 结论 临床上对考虑新生儿败血症的患儿应重视对CRP、 IL-6、 PCT的检测, 有利于早期确诊并对病情的严重程度作出判断, 减少不良事件的发生率, 值得临床推广和应用.
目的 探討聯閤檢測血清白介素-6 (IL-6)、 降鈣素原 (PCT)、 C反應蛋白 (CRP) 在新生兒敗血癥診治中的價值和意義. 方法 按照隨機、 雙盲、 對照的原則將2012年2月至2015年2月間來我院新生兒科住院治療的100例新生兒敗血癥患兒作為觀察組, 抽取同一時間段來新生兒科就診的100例非敗血癥患兒作為對照組, 分彆檢測兩組患兒血清CRP、 IL-6、 PCT.結果 觀察組患兒的血清CRP、 IL-6、 PCT水平顯著高于對照組患兒 (P<0.05); 血清CRP、 IL-6、 PCT聯閤檢測其靈敏度、暘性預測值、 陰性預測值和單一檢測相比均顯著升高 (P<0.05); 患兒CRP、 IL-6、 PCT和器官功能衰竭評估 (SOFA) 呈正相關, 而和危重評分繫統 (PCIS) 評分呈負相關. 結論 臨床上對攷慮新生兒敗血癥的患兒應重視對CRP、 IL-6、 PCT的檢測, 有利于早期確診併對病情的嚴重程度作齣判斷, 減少不良事件的髮生率, 值得臨床推廣和應用.
목적 탐토연합검측혈청백개소-6 (IL-6)、 강개소원 (PCT)、 C반응단백 (CRP) 재신생인패혈증진치중적개치화의의. 방법 안조수궤、 쌍맹、 대조적원칙장2012년2월지2015년2월간래아원신생인과주원치료적100례신생인패혈증환인작위관찰조, 추취동일시간단래신생인과취진적100례비패혈증환인작위대조조, 분별검측량조환인혈청CRP、 IL-6、 PCT.결과 관찰조환인적혈청CRP、 IL-6、 PCT수평현저고우대조조환인 (P<0.05); 혈청CRP、 IL-6、 PCT연합검측기령민도、양성예측치、 음성예측치화단일검측상비균현저승고 (P<0.05); 환인CRP、 IL-6、 PCT화기관공능쇠갈평고 (SOFA) 정정상관, 이화위중평분계통 (PCIS) 평분정부상관. 결론 림상상대고필신생인패혈증적환인응중시대CRP、 IL-6、 PCT적검측, 유리우조기학진병대병정적엄중정도작출판단, 감소불량사건적발생솔, 치득림상추엄화응용.
Objective To explore the clinical value and significance of combined detection of serum C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) in the diagnosis and treatment of neonatal sepsis. Methods 100 cases of newborns with sepsis in Neonatology Departmen of our hospital from February 2012 to February 2015 were selected as observation group, and 100 cases without sepsis in Neonatology Departmen of our hospitat at the same time were selected as control group. The levels of serum CRP, IL-6 and PCT of the two groups were detected and analyzed. Results The levels of serum CRP, IL-6 and PCT of the observation group were significantly higher than those of the control group (P<0.05). The sensitivity, positive predictive value and negative predictive value of combined detection of three indicators were significantly higher than those of detection of single indicator (P<0.05). The levels of serum CRP, IL-6 and PCT of neonatal sepsis were positively associated with sequential organ failure assessment (SOFA), and negatively associated with pediatric critical illness score (PCIS). Conclusions For newborns with suspected sepsis, the detection of serum of CRP, IL-6 and PCT is conducive to early diagnosis and disease condition assessment, so as to reduce the incidence of adverse events, which is worthy of clinical application.
