CAJ | 학술논문

作为头颈部恶性肿瘤治疗的一种重要手段，放射治疗不可避免地会对周围正常的骨组织产生副作用。利用体外细胞模型，研究证实射线可抑制成骨细胞的增殖，引起DNA分子损伤以及细胞周期的改变，而射线对其分化能力的影响结论却并不一致。该文就电离辐射对体外培养成骨细胞的影响研究作一综述。
작위두경부악성종류치료적일충중요수단，방사치료불가피면지회대주위정상적골조직산생부작용。이용체외세포모형，연구증실사선가억제성골세포적증식，인기DNA분자손상이급세포주기적개변，이사선대기분화능력적영향결론각병불일치。해문취전리복사대체외배양성골세포적영향연구작일종술。
As an important modality in the treatment of head and neck malignancies ,radiation therapy has adverse side effects on re-gional normal osseous tissue inevitably .Using in vitro cell model ,the studies confirmed that ionizing radiation inhibited the proliferation of the osteoblasts .Additionally ,it induced DNA damage and cell cycle arrest in osteoblasts .However ,the influence of ionizing radiation on cellular differentiation was not consistent .This paper reviewed of the effects of ionizing radiation on osteoblasts in vitro .