CAJ | 학술논문

目的：观察汉族与维吾尔族肾透明细胞癌患者之间血清氨基酸的变化，筛选差异氨基酸，并利用ROC曲线探讨差异氨基酸在两族肾透明细胞癌诊断中的临床价值。方法运用高效液相色谱法检测新疆地区96例肾透明细胞癌患者（汉族48例、维吾尔族48例）与96例健康人（汉族48例、维吾尔族48例）血清中的17种氨基酸含量，通过组间均值比较出两民族肾癌患者间的差异氨基酸，并运用ROC曲线评价差异氨基酸的诊断价值。结果汉、维两族肾透明细胞癌患者除谷氨酸外，其余氨基酸含量均降低，且差异具有统计学意义（P＜0．05）。两族肾透明细胞癌患者之间存在差异的氨基酸为天冬氨酸、甘氨酸及络氨酸。三种差异氨基酸对应的汉族ROC曲线下面积为0．536、0．812及0．814，对应的维族ROC曲线下面积为0．676、0．804及0．876。结论新疆地区汉族与维族肾透明细胞癌患者之间有差异的血清氨基酸为天冬氨酸、甘氨酸及络氨酸。其中两民族均以络氨酸的AUCROC最大，诊断价值最高。
목적：관찰한족여유오이족신투명세포암환자지간혈청안기산적변화，사선차이안기산，병이용ROC곡선탐토차이안기산재량족신투명세포암진단중적림상개치。방법운용고효액상색보법검측신강지구96례신투명세포암환자（한족48례、유오이족48례）여96례건강인（한족48례、유오이족48례）혈청중적17충안기산함량，통과조간균치비교출량민족신암환자간적차이안기산，병운용ROC곡선평개차이안기산적진단개치。결과한、유량족신투명세포암환자제곡안산외，기여안기산함량균강저，차차이구유통계학의의（P＜0．05）。량족신투명세포암환자지간존재차이적안기산위천동안산、감안산급락안산。삼충차이안기산대응적한족ROC곡선하면적위0．536、0．812급0．814，대응적유족ROC곡선하면적위0．676、0．804급0．876。결론신강지구한족여유족신투명세포암환자지간유차이적혈청안기산위천동안산、감안산급락안산。기중량민족균이락안산적AUCROC최대，진단개치최고。
ABSTRACT:Objective To observe the difference in serum amino acid in patients with renal clear cell carcinoma (RCCC) between Han and Uygur nationalities ,and to screen differentially expressed serum amino acid ,and to explore the diagnostic value of amino acid detection in RCCC .Methods High performance liquid chromatography (HPLC) was used to detect 17 kinds of amino acids in 96 RCCC cases (48 Han ,48 Uygur) ,and in 96 healthy controls (48 Han ,48 Uygur) in Xinjiang re‐gion .The mean contents of amino acids were compared ,and the diagnostic value of amino acids was assessed with ROC curve . Results Except for glutamic acid ,the other amino acids were lower in RCCC patients than in healthy controls ,and the difference was statistically significant (P<0 .05) .There were differences in aspartate ,glycine and tyrosine between the Han and Uygur RCCC patients .The area under ROC curve for the three amino acids was 0 .536 ,0 .812 and 0 .814 for Han national‐ity ,and 0 .676 ,0 .804 and 0 .876 for Uygur nationality .Conclusion There were differences in serum aspartate ,glycine and tyrosine between Han and Uygur RCCC patients .Tyrosine has the largest AUCROC and highest diagnostic value .