CAJ | 학술논문

目的：比较索非那新（SOL）联合坦索罗辛（TAM）与单用TAM 治疗前列腺增生合并膀胱过度活动症的有效性及安全性。方法检索国内外SOL＋ TAM与单用TAM治疗前列腺增生合并膀胱过度活动症患者疗效，按预定的纳入标准筛选出6篇研究进行质量评价，提取数据进行 Mete分析。结果 SOL＋ TAM显著降低前列腺症状评分－2.18，95％ CI（－3．80，－0．56），提高最大尿流率0．8，95％ CI（0．04，1．56），降低膀胱过度活动症评分－3．05，95％ CI（－5．11，－0．98），尿潴留的发生率为1．3％。结论现有研究证实了SOL＋ TAM比单用TAM能有效地缓解前列腺增生下尿路症状和膀胱过度活动症状，而其发生尿潴留的绝对风险偏低。SOL＋ TAM值得推荐前列腺增生合并膀胱过度活动症患者的临床用药。
목적：비교색비나신（SOL）연합탄색라신（TAM）여단용TAM 치료전렬선증생합병방광과도활동증적유효성급안전성。방법검색국내외SOL＋ TAM여단용TAM치료전렬선증생합병방광과도활동증환자료효，안예정적납입표준사선출6편연구진행질량평개，제취수거진행 Mete분석。결과 SOL＋ TAM현저강저전렬선증상평분－2.18，95％ CI（－3．80，－0．56），제고최대뇨류솔0．8，95％ CI（0．04，1．56），강저방광과도활동증평분－3．05，95％ CI（－5．11，－0．98），뇨저류적발생솔위1．3％。결론현유연구증실료SOL＋ TAM비단용TAM능유효지완해전렬선증생하뇨로증상화방광과도활동증상，이기발생뇨저류적절대풍험편저。SOL＋ TAM치득추천전렬선증생합병방광과도활동증환자적림상용약。
ABSTRACT:Objective To investigate the efficacy and safety of solifenacin (SOL) plus tamsulosin (TAM) in the treat‐ment of prostatic hyperplasia complicated with overactive bladder .Methods Clinical trails on SOL + TAM and TAM alone to treat prostatic hyperplasia complicated with overactive bladder were searched .Altogether 6 trails were included .Data were then analyzed ,including changes in International Prostate Symptom Score (IPSS) ,IPSS‐QOL (quality of life) ,maximal urina‐ry flow rate (Qmax) ,and Overactive Bladder Symptom Scores (OABSS) .Results Combined therapy could significantly re‐duce IPSS -2 .18 ,95% CI (-3 .80 ,-0 .56) ,reduce OABSS -3 .05 ,95% CI (-5 .11 ,-0 .98) ,and improve the maximal u‐rinary flow rate 0 .8 ,95% CI (0 .04 ,1 .56) .The incidence of urinary retention was 1 .3% .Conclusions The combined treatment of solifenacin plus tamsulosin significantly reduces IPSS and OABSS .This approach is safe with a minimal risk of a‐cute urinary retention .It is worth wide clinical application .