临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
Chinese Journal of Clinical Rational Drug Use
2015年
33期
13-15
,共3页
糖尿病肾病%吡格列酮%厄贝沙坦%阿托伐他汀%治疗结果
糖尿病腎病%吡格列酮%阨貝沙坦%阿託伐他汀%治療結果
당뇨병신병%필격렬동%액패사탄%아탁벌타정%치료결과
Diabetic nephropathies%Pioglitazone%Irbesartan%Atorvastatin%Treatment outcome
目的：探讨吡格列酮联合厄贝沙坦及阿托伐他汀治疗早期糖尿病肾病的临床疗效。方法选取2011—2014年魏县人民医院收治的早期糖尿病肾病患者114例，随机分为对照组55例和观察组59例。两组患者均给予胰岛素及吡格列酮、厄贝沙坦治疗，观察组另加用阿托伐他汀治疗。观察两组患者治疗前后的血脂及肾功能变化情况。结果治疗前两组患者的血脂及肾功能比较，差异无统计学意义（ P ＞0.05）；治疗后观察组患者的总胆固醇、三酰甘油、低密度脂蛋白、血肌酐、血尿素氮水平及尿微量清蛋白、尿微量清蛋白排泄量均低于对照组（P ＜0.05），而两组高密度脂蛋白水平比较，差异无统计学意义（P ＞0.05）。两组不良反应发生率比较，差异无统计学意义（P ＞0.05）。结论吡格列酮联合厄贝沙坦及阿托伐他汀治疗早期糖尿病肾病的临床疗效确切，可有效改善患者血脂代谢及肾功能。
目的：探討吡格列酮聯閤阨貝沙坦及阿託伐他汀治療早期糖尿病腎病的臨床療效。方法選取2011—2014年魏縣人民醫院收治的早期糖尿病腎病患者114例，隨機分為對照組55例和觀察組59例。兩組患者均給予胰島素及吡格列酮、阨貝沙坦治療，觀察組另加用阿託伐他汀治療。觀察兩組患者治療前後的血脂及腎功能變化情況。結果治療前兩組患者的血脂及腎功能比較，差異無統計學意義（ P ＞0.05）；治療後觀察組患者的總膽固醇、三酰甘油、低密度脂蛋白、血肌酐、血尿素氮水平及尿微量清蛋白、尿微量清蛋白排洩量均低于對照組（P ＜0.05），而兩組高密度脂蛋白水平比較，差異無統計學意義（P ＞0.05）。兩組不良反應髮生率比較，差異無統計學意義（P ＞0.05）。結論吡格列酮聯閤阨貝沙坦及阿託伐他汀治療早期糖尿病腎病的臨床療效確切，可有效改善患者血脂代謝及腎功能。
목적：탐토필격렬동연합액패사탄급아탁벌타정치료조기당뇨병신병적림상료효。방법선취2011—2014년위현인민의원수치적조기당뇨병신병환자114례，수궤분위대조조55례화관찰조59례。량조환자균급여이도소급필격렬동、액패사탄치료，관찰조령가용아탁벌타정치료。관찰량조환자치료전후적혈지급신공능변화정황。결과치료전량조환자적혈지급신공능비교，차이무통계학의의（ P ＞0.05）；치료후관찰조환자적총담고순、삼선감유、저밀도지단백、혈기항、혈뇨소담수평급뇨미량청단백、뇨미량청단백배설량균저우대조조（P ＜0.05），이량조고밀도지단백수평비교，차이무통계학의의（P ＞0.05）。량조불량반응발생솔비교，차이무통계학의의（P ＞0.05）。결론필격렬동연합액패사탄급아탁벌타정치료조기당뇨병신병적림상료효학절，가유효개선환자혈지대사급신공능。
Objective To explore the effect of pioglitazone combined with irbesartan and atorvastatin in the treatment of early - stage diabetic nephropathy. Methods A total of 114 patients with early - stage diabetic nephropathy were selected from 2011 to 2014 in the People's Hospital of Wei County,they were randomly divided into control group(55 cases)and ob-servation group(59 cases). The two groups were all given insulin and pioglitazone,irbesartan,the observation group were giv-en extra atorvastatin. The blood fat and renal function before and after treatment were compared between the two groups. Results There was no statistically significant differences in blood fat and renal function between the two groups before treatment(P >0. 05);after treatment total cholesterol,triacylglycerol,low density lipoprotein,serum creatinine,blood urea nitrogen levels and urinary albumin excretion,urine trace albumin excretion were lower than control group(P < 0. 05). The high - density lip-oprotein,adverse reaction rate between the two groups showed no significant differences(P > 0. 05). Conclusion The effect of pioglitazone combined with irbesartan and atorvastatin are sure in the treatment of early - stage diabetic nephropathy,can ef-fectively reduce the blood fat levels of patients,improve the renal function.
