CAJ | 학술논문

目的：评价帕罗西汀治疗老年冠心病伴发抑郁症的临床特征及干预治疗。方法整群选取该院2012年1月-2015年1月心内科住院82例老年妇女冠心病合并抑郁症患者，随机分组对照组41例，治疗组41例，对照组采用常规冠心病治疗方法，治疗组在对照组的基础上采用常规冠心病治疗方案联合盐酸帕罗西汀进行治疗。结果观察对照组和治疗组上接受治疗后HAMD评分别为(31.25±3.15)及(9.74±1.97)(P<0.01)。对两种患者治疗后发作持续时间、心绞痛发作次数、硝酸甘油用量、ST段压低导联数等比较差异有统计学意义(P<0.01)。结论盐酸帕罗西汀抗抑郁治疗后，老年冠心病伴发抑郁症者的抑郁症状的到了明显改善。
목적：평개파라서정치료노년관심병반발억욱증적림상특정급간예치료。방법정군선취해원2012년1월-2015년1월심내과주원82례노년부녀관심병합병억욱증환자，수궤분조대조조41례，치료조41례，대조조채용상규관심병치료방법，치료조재대조조적기출상채용상규관심병치료방안연합염산파라서정진행치료。결과관찰대조조화치료조상접수치료후HAMD평분별위(31.25±3.15)급(9.74±1.97)(P<0.01)。대량충환자치료후발작지속시간、심교통발작차수、초산감유용량、ST단압저도련수등비교차이유통계학의의(P<0.01)。결론염산파라서정항억욱치료후，노년관심병반발억욱증자적억욱증상적도료명현개선。
Objective To evaluate the clinical features of paroxetine in the treatment of senile coronary heart disease asso-ciated with depression and discuss the effect of intervention therapy. Methods 82 aged women with coronary heart disease associated with depression hospitalized in the department of cardiology from January 2012 and January 2015 were investigated and randomly divided into control group and treatment group with 41 in each one. The control group was given conventional treatment of coronary heart disease, while those in the treatment group underwent conventional treatment of coronary heart disease associated with paroxetine. Results After treatment, the HADM scores were (31.25±3.15) in the control group and(9.74±1.97)in the treatment group respectively, P<0.01. After treatment, with respect to attack duration, angina attack fre-quency, nitroglycerin consumption, amount of ST segment depression, statistically significant differences can be found between the patients in the two groups, P<0.01. Conclusion Anti-depressant treatment using paroxetine hydrochloride can significantly lower the depression degree of aged patients suffering from coronary heart disease associated with depression.