CAJ | 학술논문

目的：探讨动脉粥样硬化性颈动脉狭窄与血清骨桥蛋白水平间的关系。方法选取我院住院及门诊经颈动脉彩超筛查的动脉粥样硬化性颈动脉狭窄患者80例，设为颈动脉狭窄组，同时选取年龄、性别相匹配的健康体检者80例，设为非颈动脉狭窄组，检测颈动脉狭窄组患者颈动脉斑块的特点，同时记录和检测2组人群的年龄、性别、收缩压、低密度脂蛋白、空腹血糖、同型半胱氨酸水平、体重指数（ BMI）等，此外，利用ELISA方法检查两组人群血清中骨桥蛋白水平。结果80例颈动脉狭窄患者中，稳定斑块34例，不稳定斑块46例。与非颈动脉狭窄组比较，颈动脉狭窄组患者的收缩压、低密度脂蛋白、空腹血糖、同型半胱氨酸水平、BMI均明显升高（ P均＜0．05）；颈动脉狭窄组患者的血清骨桥蛋白水平较非颈动脉狭窄组高（ P＜0．01）。多元逐步回归分析表明颈动脉狭窄与患者的性别、低密度脂蛋白、骨桥蛋白水平有关（B＝0．022～0．047，P均＜0．05）。结论血清骨桥蛋白可能参与了颈动脉粥样硬化的形成。
목적：탐토동맥죽양경화성경동맥협착여혈청골교단백수평간적관계。방법선취아원주원급문진경경동맥채초사사적동맥죽양경화성경동맥협착환자80례，설위경동맥협착조，동시선취년령、성별상필배적건강체검자80례，설위비경동맥협착조，검측경동맥협착조환자경동맥반괴적특점，동시기록화검측2조인군적년령、성별、수축압、저밀도지단백、공복혈당、동형반광안산수평、체중지수（ BMI）등，차외，이용ELISA방법검사량조인군혈청중골교단백수평。결과80례경동맥협착환자중，은정반괴34례，불은정반괴46례。여비경동맥협착조비교，경동맥협착조환자적수축압、저밀도지단백、공복혈당、동형반광안산수평、BMI균명현승고（ P균＜0．05）；경동맥협착조환자적혈청골교단백수평교비경동맥협착조고（ P＜0．01）。다원축보회귀분석표명경동맥협착여환자적성별、저밀도지단백、골교단백수평유관（B＝0．022～0．047，P균＜0．05）。결론혈청골교단백가능삼여료경동맥죽양경화적형성。
Objective To investigate the relationship between serum steopontin and atherosclerotic carotid stenosis. Methods A total of 80 patients who were diagnosed with atherosclerotic carotid stenosis by carotid ultrasound were in-cluded in this study.Meanwhile, another 80 age and sex-matched healthy subjects were also enrolled as controls.The characteristics of carotid plaques in patients with atherosclerotic carotid stenosis were detected.Then, both groups were compared for age, gender, systolic blood pressure, low density lipoprotein, fasting blood glucose, homocysteine levels and body mass index ( BMI) .The levels of serum osteopontin in patients of both groups were measured by ELISA.Re-sults Among the patients with atherosclerotic carotid stenosis were 34 patients with stable plaques and 46 ones with un-stable plaques.Compared with the control, remarkably increases were observed as to systolic blood pressure, low density lipoprotein, fasting blood glucose, homocysteine level and BMI in the atherosclerotic carotid stenosis group ( all P <0.05).The atherosclerotic carotid stenosis group also produced higher quantities of serum osteopontin, in comparison with the control (P<0.01).According to multiple stepwise regression analysis, atherosclerotic carotid stenosis was cor-related with patients′gender, and the levels of low density lipoprotein and osteopontin ( B=0.022 -0.047, all P<0.05).Conclusion Osteopontin may be involved in the formation of atherosclerotic carotid stenosis.