解放军医药杂志
解放軍醫藥雜誌
해방군의약잡지
Medical & Pharmaceutical Journal of Chinese People's Liberation Army
2015年
11期
102-105
,共4页
中药%特异性免疫%过敏性哮喘%儿童
中藥%特異性免疫%過敏性哮喘%兒童
중약%특이성면역%과민성효천%인동
Drugs,Chinese herbal%Specific immunity%Allergic asthma%Children
目的：观察中药联合特异性免疫治疗小儿过敏性哮喘的临床效果。方法选择北京航天总医院2010年2月—2013年11月收治的确诊为过敏性哮喘的患儿236例随机分成对照组和观察组，每组118例。对照组予标准化特异性免疫治疗，观察组在对照组基础上加服红参片及自拟去敏方剂治疗，疗程为12个月。观察比较两组疗效，治疗前及治疗后2、3、4、5、6、12个月的症状评分、呼气流量峰值( PEF)变化，治疗期间急性发作次数及不良反应发生率。结果观察组总有效率显著高于对照组(P<0．01)。与本组治疗前比较，观察组症状评分、PEF治疗后5个月开始显著下降(P<0．01)，对照组直到治疗后6个月才开始显著下降(P<0．01)；观察组治疗后5、6、12个月症状评分及PEF显著低于对照组(P<0．01)。观察组治疗期间急性发作次数与不良反应发生率均显著低于对照组(P<0．01)。结论采用中药联合特异性免疫治疗能改善过敏性哮喘患儿的免疫功能，减少复发，降低不良反应发生率，效果满意。
目的：觀察中藥聯閤特異性免疫治療小兒過敏性哮喘的臨床效果。方法選擇北京航天總醫院2010年2月—2013年11月收治的確診為過敏性哮喘的患兒236例隨機分成對照組和觀察組，每組118例。對照組予標準化特異性免疫治療，觀察組在對照組基礎上加服紅參片及自擬去敏方劑治療，療程為12箇月。觀察比較兩組療效，治療前及治療後2、3、4、5、6、12箇月的癥狀評分、呼氣流量峰值( PEF)變化，治療期間急性髮作次數及不良反應髮生率。結果觀察組總有效率顯著高于對照組(P<0．01)。與本組治療前比較，觀察組癥狀評分、PEF治療後5箇月開始顯著下降(P<0．01)，對照組直到治療後6箇月纔開始顯著下降(P<0．01)；觀察組治療後5、6、12箇月癥狀評分及PEF顯著低于對照組(P<0．01)。觀察組治療期間急性髮作次數與不良反應髮生率均顯著低于對照組(P<0．01)。結論採用中藥聯閤特異性免疫治療能改善過敏性哮喘患兒的免疫功能，減少複髮，降低不良反應髮生率，效果滿意。
목적：관찰중약연합특이성면역치료소인과민성효천적림상효과。방법선택북경항천총의원2010년2월—2013년11월수치적학진위과민성효천적환인236례수궤분성대조조화관찰조，매조118례。대조조여표준화특이성면역치료，관찰조재대조조기출상가복홍삼편급자의거민방제치료，료정위12개월。관찰비교량조료효，치료전급치료후2、3、4、5、6、12개월적증상평분、호기류량봉치( PEF)변화，치료기간급성발작차수급불량반응발생솔。결과관찰조총유효솔현저고우대조조(P<0．01)。여본조치료전비교，관찰조증상평분、PEF치료후5개월개시현저하강(P<0．01)，대조조직도치료후6개월재개시현저하강(P<0．01)；관찰조치료후5、6、12개월증상평분급PEF현저저우대조조(P<0．01)。관찰조치료기간급성발작차수여불량반응발생솔균현저저우대조조(P<0．01)。결론채용중약연합특이성면역치료능개선과민성효천환인적면역공능，감소복발，강저불량반응발생솔，효과만의。
Objective To observe the clinical effect of traditional Chinese medicine combined with specific im-munotherapy in treatment of children with allergic asthma. Methods A total of 236 children diagnosed as having allergic asthma during February 2010 and November 2013 were randomly divided into control group ( n=118 ) and observation group (n=118). The control group was treated with standardized specific immunotherapy, while the observation group was treated with Red Ginseng slice and self-desensitization prescription treatment based on the standardized specific im-munotherapy, and the course of treatment was 12 months. The efficacy of the two groups was compared, and symptom scores and peak expiratory flow ( PEF) changes before and in the 2 nd , 3 rd , 4 th , 5 th , 6 th and 12 th months after the treat-ment, frequency of acute episode and incidence rate of adverse reaction during the treatment were also observed and com-pared in the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group (P<0. 01). Compared with those before the treatment, the values of symptom score and PEF began to sig-nificantly decrease in the 5th month after the treatment in the observation group (P<0. 01), and the control group, while the values began to significantly decrease in the 6th month after the treatment (P<0. 01). The values of symptom scores and PEF in the observation group in the 5 th , 6 th and 12 th months after the treatment were significantly lower than those in the control group (P<0. 01). During the treatment, the values of frequency of acute episode and the incidence rate of adverse reactions in the observation group were significantly lower than those in the control group (P<0. 01). Conclu-sion The traditional Chinese medicine combined with specific immunotherapy in treatment of children with allergic asth-ma can improve the immune function, reduce the recurrence rate and incidence rate of adverse reaction.
