中外医疗
中外醫療
중외의료
China Foreign Medical Treatment
2015年
31期
84-86
,共3页
宫颈癌%宫颈上皮内瘤样病变%hpv分型
宮頸癌%宮頸上皮內瘤樣病變%hpv分型
궁경암%궁경상피내류양병변%hpv분형
Cervical cancer%Cervical intraepithelial neoplasia%HPV types
目的：探讨宫颈上皮内瘤样病变级别与宫颈癌和HPV亚型的关联。方法整群选取该院2012年12月-2014年12月收治的宫颈癌、宫颈上皮内瘤样病变患者290例作为研究对象，回顾性分析其临床资料。其中宫颈癌组42例，依据宫颈上皮内瘤样病变级别将248例划分为宫颈上皮内瘤样病变(CIN)I(n=140)、II(n=48)以及III组(n=60)。检测四组患者HPV水平，探讨病变级别与HPV分型之间存在的关联。结果①宫颈病变不同高危型HPV亚型也存在差异，CINI主要感染亚型为HPV16、52、58以及31，CINII至 III则主要为 HPV16、33、58以及31；宫颈癌组主要为HPV16、52以及58，说明在宫颈不同程度病变中HPV16与58为主要感染亚型；②CINIhpv16感染率为32.1%，CINII为54.2%，CINIII为60.0%，宫颈癌为85.7%，对比差异有统计学意义(P<0.05)；③CINI高危型HPV感染率为89.3%，CINII-III为91.7%，宫颈癌为100.0%，对比差异无统计学意义(P>0.05)。结论 HPV16与58为宫颈病变主要感染亚型，且其病变与高危型hpv感染呈正相关。
目的：探討宮頸上皮內瘤樣病變級彆與宮頸癌和HPV亞型的關聯。方法整群選取該院2012年12月-2014年12月收治的宮頸癌、宮頸上皮內瘤樣病變患者290例作為研究對象，迴顧性分析其臨床資料。其中宮頸癌組42例，依據宮頸上皮內瘤樣病變級彆將248例劃分為宮頸上皮內瘤樣病變(CIN)I(n=140)、II(n=48)以及III組(n=60)。檢測四組患者HPV水平，探討病變級彆與HPV分型之間存在的關聯。結果①宮頸病變不同高危型HPV亞型也存在差異，CINI主要感染亞型為HPV16、52、58以及31，CINII至 III則主要為 HPV16、33、58以及31；宮頸癌組主要為HPV16、52以及58，說明在宮頸不同程度病變中HPV16與58為主要感染亞型；②CINIhpv16感染率為32.1%，CINII為54.2%，CINIII為60.0%，宮頸癌為85.7%，對比差異有統計學意義(P<0.05)；③CINI高危型HPV感染率為89.3%，CINII-III為91.7%，宮頸癌為100.0%，對比差異無統計學意義(P>0.05)。結論 HPV16與58為宮頸病變主要感染亞型，且其病變與高危型hpv感染呈正相關。
목적：탐토궁경상피내류양병변급별여궁경암화HPV아형적관련。방법정군선취해원2012년12월-2014년12월수치적궁경암、궁경상피내류양병변환자290례작위연구대상，회고성분석기림상자료。기중궁경암조42례，의거궁경상피내류양병변급별장248례화분위궁경상피내류양병변(CIN)I(n=140)、II(n=48)이급III조(n=60)。검측사조환자HPV수평，탐토병변급별여HPV분형지간존재적관련。결과①궁경병변불동고위형HPV아형야존재차이，CINI주요감염아형위HPV16、52、58이급31，CINII지 III칙주요위 HPV16、33、58이급31；궁경암조주요위HPV16、52이급58，설명재궁경불동정도병변중HPV16여58위주요감염아형；②CINIhpv16감염솔위32.1%，CINII위54.2%，CINIII위60.0%，궁경암위85.7%，대비차이유통계학의의(P<0.05)；③CINI고위형HPV감염솔위89.3%，CINII-III위91.7%，궁경암위100.0%，대비차이무통계학의의(P>0.05)。결론 HPV16여58위궁경병변주요감염아형，차기병변여고위형hpv감염정정상관。
Objective To explore the association between cervical cancer, cervical intraepithelial neoplasia (CIN) grade and HPV subtypes. Methods 290 patients with cervical cancer or cervical intraepithelial neoplasia admitted to this hospital from December 2012 and December 2014 were included in this study and their clinical data was retrospectively analyzed. 42 patients were assigned to the cervical cancer group and the other 248 were divided into CIN grade I group (n=140), CIN grade II group(n=48)and CIN grade III group(n=60)according to the CIN grade. The level of HPV of all the patients in the four groups was detected and the association between CIN grades and HPV subtypes were investigated. Results ①The HPV subtypes of patients varied with their CIN grades: the main subtypes of HPV infection were HPV16, HPV52, HPV58 and HPV 31 in patients in CIN grade I group but were HPV16, HPV33, HPV58 and HPV 31 in patients in CIN grade II and III group and were HPV16, HPV52, HPV58 in patients in cervical cancer group, which meant that HPV16 and HPV58 were the main HPV subtypes for all patients with different levels of cervical neoplasia in the four group. ②The HPV16 infection rate was 32.1% in the CIN grade I group, 54.2% in the CIN grade II, 60.0% in the CIN grade III group and 85.7% in the cervical cancer group, and the differences between the four groups were statistically significant, P<0.05. ③The infection rate high-risk HPV was 89.3% in patients with CIN grade I, was 91.7% in patients with CIN grade II and CIN grade III, and was 100.0% in patients with cervical cancer, and no statistically significant difference can be found between the three, P>0.05. Conclusion HPV16 and HPV58 were the main subtypes in patients with cervical neoplasia and high-risk HPV in-fection is positively correlated with this disease.
