CAJ | 학술논문

目的：比较多囊卵巢综合征( PCOS)患者与正常女性对照人群两组之间血浆血管活性肠肽( VIP)水平的差异,初步探讨VIP在PCOS发生、发展中的潜在病理意义。方法检测体重指数、血浆VIP和性激素水平,分析血浆VIP水平与体重指数、性激素水平的相关性。结果 PCOS患者血浆VIP水平显著低于健康对照女性(408.49±25.80 vs 663.85±71.17 ng/L,P<0.05)。所有受试者血浆VIP水平与体重指数、LH/FSH比值、血浆睾酮浓度呈显著负相关(P<0.05)。结论 VIP可能参与PCOS的病理生理过程,能否作为诊断PCOS或判断其预后的一种新的血浆生物标记物,并成为潜在的治疗新靶点,有待进一步研究证实。
목적：비교다낭란소종합정( PCOS)환자여정상녀성대조인군량조지간혈장혈관활성장태( VIP)수평적차이,초보탐토VIP재PCOS발생、발전중적잠재병리의의。방법검측체중지수、혈장VIP화성격소수평,분석혈장VIP수평여체중지수、성격소수평적상관성。결과 PCOS환자혈장VIP수평현저저우건강대조녀성(408.49±25.80 vs 663.85±71.17 ng/L,P<0.05)。소유수시자혈장VIP수평여체중지수、LH/FSH비치、혈장고동농도정현저부상관(P<0.05)。결론 VIP가능삼여PCOS적병리생리과정,능부작위진단PCOS혹판단기예후적일충신적혈장생물표기물,병성위잠재적치료신파점,유대진일보연구증실。
Objective To evaluate the difference in plasma level of vasoactive intestinal peptide ( VIP) between pa-tients with polycystic ovary syndrome ( PCOS) and healthy control subjects,and to explore its potential pathological signifi-cance in the genesis and development of PCOS. Methods The body mass index and plasma concentrations of VIP and sex hormone were measured. The relationship between plasma level of VIP with hormonal and metabolic parameters was ana-lyzed. Results The plasma levels of VIP in PCOS patients were significantly lower than that of healthy control subjects (408. 49 ± 25. 80 vs 663. 85 ± 71. 17 ng/L,P<0. 05). There was a significantly negative correlation between the plasma VIP concentration with body mass index, LH/FSH ratio and the plasma testosterone concentration in two groups together (P<0. 05). Conclusion VIP may participate in the pathophysiological process of PCOS. Whether VIP may be used as a novel plasma biomarker or a prognostic factor for PCOS and as a potential therapeutic target in the clinical setting needs to be further investigated.