肝脏
肝髒
간장
Chinese Hepatology
2015年
11期
841-843
,共3页
HBV%HEV%肝炎%重叠感染
HBV%HEV%肝炎%重疊感染
HBV%HEV%간염%중첩감염
Hepatitis B virus%Hepatitis E virus%Hepatitis%Overlapping infection
目的了解慢性 HBV 感染重叠感染 HEV 患者的临床特征及疾病转归。方法慢性乙型肝炎患者重叠感染 HEV（HBV＋HEV 组）患者62例；慢性乙型肝炎感染（HBV 组）患者50例。ELISA 检测两组患者的 HBV 标志物，实时荧光定量 PCR 法检测 HBV DNA，同时检测其肝功能指标。结果 HBV＋ HEV 组 TBil、ALT、AST 和 PT 分别为（260．33±32．47）μmol／L、（373．92±105．84）U／L、（510．32±167．25）U／L 和（20．08±3．69）s，HBV 组分别为（216．22±42．67）μmol／L、（339．62±98．36）U／L、（429．13±112．44）U／L、（16．79±2．34）s，且均差异有统计学意义（P ＜0．05），Alb两组间无差异；TBil 恢复正常的时间 HBV＋HEV 组患者为（45．6±8．4）d，HBV 组患者为（24．3±5．8）d，重叠感染患者恢复时间延长（P ＜0．05），HBV＋HEV 组的重型肝炎的发病率（30．6％）和病死率（12．9％）均显著高于 HBV 组的14．0％和0，且均差异有统计学意义（P ＜0．05）。结论 HEV 重叠感染慢性 HBV 对患者的肝功能及其疾病转归均有严重影响。
目的瞭解慢性 HBV 感染重疊感染 HEV 患者的臨床特徵及疾病轉歸。方法慢性乙型肝炎患者重疊感染 HEV（HBV＋HEV 組）患者62例；慢性乙型肝炎感染（HBV 組）患者50例。ELISA 檢測兩組患者的 HBV 標誌物，實時熒光定量 PCR 法檢測 HBV DNA，同時檢測其肝功能指標。結果 HBV＋ HEV 組 TBil、ALT、AST 和 PT 分彆為（260．33±32．47）μmol／L、（373．92±105．84）U／L、（510．32±167．25）U／L 和（20．08±3．69）s，HBV 組分彆為（216．22±42．67）μmol／L、（339．62±98．36）U／L、（429．13±112．44）U／L、（16．79±2．34）s，且均差異有統計學意義（P ＜0．05），Alb兩組間無差異；TBil 恢複正常的時間 HBV＋HEV 組患者為（45．6±8．4）d，HBV 組患者為（24．3±5．8）d，重疊感染患者恢複時間延長（P ＜0．05），HBV＋HEV 組的重型肝炎的髮病率（30．6％）和病死率（12．9％）均顯著高于 HBV 組的14．0％和0，且均差異有統計學意義（P ＜0．05）。結論 HEV 重疊感染慢性 HBV 對患者的肝功能及其疾病轉歸均有嚴重影響。
목적료해만성 HBV 감염중첩감염 HEV 환자적림상특정급질병전귀。방법만성을형간염환자중첩감염 HEV（HBV＋HEV 조）환자62례；만성을형간염감염（HBV 조）환자50례。ELISA 검측량조환자적 HBV 표지물，실시형광정량 PCR 법검측 HBV DNA，동시검측기간공능지표。결과 HBV＋ HEV 조 TBil、ALT、AST 화 PT 분별위（260．33±32．47）μmol／L、（373．92±105．84）U／L、（510．32±167．25）U／L 화（20．08±3．69）s，HBV 조분별위（216．22±42．67）μmol／L、（339．62±98．36）U／L、（429．13±112．44）U／L、（16．79±2．34）s，차균차이유통계학의의（P ＜0．05），Alb량조간무차이；TBil 회복정상적시간 HBV＋HEV 조환자위（45．6±8．4）d，HBV 조환자위（24．3±5．8）d，중첩감염환자회복시간연장（P ＜0．05），HBV＋HEV 조적중형간염적발병솔（30．6％）화병사솔（12．9％）균현저고우 HBV 조적14．0％화0，차균차이유통계학의의（P ＜0．05）。결론 HEV 중첩감염만성 HBV 대환자적간공능급기질병전귀균유엄중영향。
Objective To investigate the clinical features and outcomes of hepatitis E virus (HEV)overlapping infection in patients with chronic hepatitis B (CHB).Methods Sixty-two patients with chronic HBV and HEV overlapping infection were enrolled as observation group,while 50 patients with chronic HBV infection were set as control group. Enzyme-linked immunosorbent (ELISA)and real-time fluorescence quantitative polymerase chain reaction (PCR)assay were performed to detect HBV markers,anti-HEV IgM and HBV load,respectively.Assessment of liver function was carried out in both groups.Results Compared to control group,overlapping infection group displayed significantly higher levels of total bilirubin (TBil),alanine aminotransferase,aspartate transaminase and prothrombin time (260.33±32.47 μmol/L vs. 216.22±42.67 μmo/L,373.92±105.84 U/L vs.339.62±98.36 U/L,510.32±167.25 U/L vs.429.13±112.44 U/L and 20.08±3.69 s vs.16.79 ±2.34 s,respectively,P <0.05 ),with no significant difference in level of albumin (P >0.05).Overlapping infection group took more time to return to normal level in serum TBil than control group (45.6±8.4 d vs.24.3±5.8 d,P <0.05).Furthermore,morbidity and mortality of severe hepatitis in overlapping infection group were significantly higher than those in control group (12.9% vs.0.0%,P <0.05).Conclusion HEV and HBV overlapping infection severely affects liver function and disease prognosis.
