中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
127-130
,共4页
羟丙甲纤维素%分子量%释放度%头孢克洛缓释片
羥丙甲纖維素%分子量%釋放度%頭孢剋洛緩釋片
간병갑섬유소%분자량%석방도%두포극락완석편
hydroxypropyl methyl cellulose%molecular weight%release characteristics%cefacor sustained-release tablets
目的 考察羟丙甲纤维素(hydroxypropyl methyl cellulose,HPMC)样品对头孢克洛缓释片的缓控释效果的影响.方法 收集不同厂商的10批羟丙甲纤维素样品,考察不同批次HPMC样品的黏度和分子量及分子量分布等特性,按固定处方以HPMC为阻滞剂制备头孢克洛缓释片,测定释放度并比较分析不同批次HPMC对特定缓释片的影响结果.结果 HPMC样品的分子量大小与样品的黏度呈正相关,分子量越大,药物释放速度越慢,缓控释效果越好.结论 不同厂商的HPMC样品质量稳定性各异,会影响制剂的缓控释效果.
目的 攷察羥丙甲纖維素(hydroxypropyl methyl cellulose,HPMC)樣品對頭孢剋洛緩釋片的緩控釋效果的影響.方法 收集不同廠商的10批羥丙甲纖維素樣品,攷察不同批次HPMC樣品的黏度和分子量及分子量分佈等特性,按固定處方以HPMC為阻滯劑製備頭孢剋洛緩釋片,測定釋放度併比較分析不同批次HPMC對特定緩釋片的影響結果.結果 HPMC樣品的分子量大小與樣品的黏度呈正相關,分子量越大,藥物釋放速度越慢,緩控釋效果越好.結論 不同廠商的HPMC樣品質量穩定性各異,會影響製劑的緩控釋效果.
목적 고찰간병갑섬유소(hydroxypropyl methyl cellulose,HPMC)양품대두포극락완석편적완공석효과적영향.방법 수집불동엄상적10비간병갑섬유소양품,고찰불동비차HPMC양품적점도화분자량급분자량분포등특성,안고정처방이HPMC위조체제제비두포극락완석편,측정석방도병비교분석불동비차HPMC대특정완석편적영향결과.결과 HPMC양품적분자량대소여양품적점도정정상관,분자량월대,약물석방속도월만,완공석효과월호.결론 불동엄상적HPMC양품질량은정성각이,회영향제제적완공석효과.
Objective To investigate effect of hydroxypropyl methyl cellulose (HPMC) to in vitro release characteristics of cefaclor sustained-release tablets.Methods Collected 10 batches of HPMC from different manufacturers.Determined the viscosity, molecular weight and the distribution of molecular weight of HPMC.HPMC from different manufacturers was used as blocking agent for the preparation of cefaclor sustained-release tablets according to the same prescription.Results The molecular weight was positively related to the viscosity of HPMC.The more molecular weight was, the slower the drugs release rate was,the better controlled released.Conclusion HPMC from different manufacturers show different quality stability and effect in vitro release of cefacor sustained-release tablets.
