CAJ | 학술논문

目的:观察平肥2号方对高脂饮食诱导的单纯性肥胖大鼠体质量、脂肪细胞、肝脏等的影响.方法:50只SD大鼠随机分为低脂组和高脂组,低脂组以低脂饲料喂养,高脂组予高脂饲料喂养诱导肥胖模型.验证成模后的大鼠随机分为模型组、奥利司他组和平肥2号方组.低脂组和模型组予以蒸馏水灌胃,奥利司他和平肥2号方组分别予以奥利司他和平肥2号方灌胃.每日记录大鼠体质量,治疗4周后取材检测大鼠脂肪细胞、肝脏和血糖血脂情况.结果:平肥2号方和奥利司他组体质量增长明显低于模型组(P<0.05);且脂肪细胞直径变小,肝脏的脂变程度得到改善;血糖血脂水平各组无显著差异.结论:平肥2号方和奥利司他都有显著的减肥效用,但相比奥利司他组大鼠表现出来的副作用,平肥2号方具有明显的优势.
목적:관찰평비2호방대고지음식유도적단순성비반대서체질량、지방세포、간장등적영향.방법:50지SD대서수궤분위저지조화고지조,저지조이저지사료위양,고지조여고지사료위양유도비반모형.험증성모후적대서수궤분위모형조、오리사타조화평비2호방조.저지조화모형조여이증류수관위,오리사타화평비2호방조분별여이오리사타화평비2호방관위.매일기록대서체질량,치료4주후취재검측대서지방세포、간장화혈당혈지정황.결과:평비2호방화오리사타조체질량증장명현저우모형조(P<0.05);차지방세포직경변소,간장적지변정도득도개선;혈당혈지수평각조무현저차이.결론:평비2호방화오리사타도유현저적감비효용,단상비오리사타조대서표현출래적부작용,평비2호방구유명현적우세.
Objective:To observe the effect of the Second Pingfei decoction on body weight, adipocyte and liver in diet-induced obesity ( DIO ) rats.Methods:50 SD rats were randomly divided into a low fat diet group (LFD) and a high fat diet group( HFD).After the DIO models were established, the successful model rats were randomly divided into an HFD group,an Orlistat group( OLST) and the Second Pingfei decoction group ( SPFD) .LFD and HFD groups were treated with distilled water by gavage.OLST and SPFD groups were trea-ted with orlistat and the Second Pingfei decoction by gavage respectively.The body weights were recorded ev-ery day.After 4 weeks, all rats were sacrificed to detect the adipocyte , liver , blood glucose and blood lipid. Results:With decreased diameter of adipocyte, the weight gain of OLST and SPFD groups was significant lower than that of HFD group( P<0.05) and the states of hepatic steatosis were improved.But there was no signifi-cant difference among all groups according to the blood glucose and blood lipid.Conclusion:Both the Second Pingfei decoction and Orlistat have the effect on weight loss.However, the Second Pingfei decoction may be a better way compared with the Orlistat.