中医药信息
中醫藥信息
중의약신식
Information on Traditional Chinese Medicine
2015年
6期
77-79
,共3页
于思明%裴春鹏%代丽娟%郭丹丹
于思明%裴春鵬%代麗娟%郭丹丹
우사명%배춘붕%대려연%곽단단
补肾健骨方%慢性肾脏病%骨代谢异常%甲状旁腺激素
補腎健骨方%慢性腎髒病%骨代謝異常%甲狀徬腺激素
보신건골방%만성신장병%골대사이상%갑상방선격소
Bushen Jiangu decoction%Chronic kidney disease%Abnormality of bone metabolism%Parathyroid hormone
目的:观察补肾健骨方治疗慢性肾脏病-矿物质和骨异常(CKD-MBD)的临床疗效.方法:将符合纳入标准的70例患者按随机数字表法分为治疗组、对照组,35例.对照组给予常规治疗,治疗组于常规治疗基础上加服补肾健骨方,疗程4周.观察两组患者的总疗效及治疗前后血清肌酐(Scr)、尿素氮(BUN)、尿酸(UA)、内生肌酐清除率(CCr)、Ca、P、全段甲状旁腺激素(iPTH)的变化;结果:治疗组有效率为82.9%,优于对照组的65.7%(P<0.05);治疗后治疗组BUN水平低于对照组(P<0.05),两组患者Scr、UA、Ca水平比较差异无统计学意义(P>0.05);两组患者血清P、iPTH水平低于治疗前(P<0.05,P<0.01),治疗组优于对照组(P<0.05).结论:补肾健骨方有助于缓解CKD-MBD患者的临床症状,并在降低尿素氮、血磷及甲状旁腺激素水平、调节钙磷代谢方面具有一定的作用.
目的:觀察補腎健骨方治療慢性腎髒病-礦物質和骨異常(CKD-MBD)的臨床療效.方法:將符閤納入標準的70例患者按隨機數字錶法分為治療組、對照組,35例.對照組給予常規治療,治療組于常規治療基礎上加服補腎健骨方,療程4週.觀察兩組患者的總療效及治療前後血清肌酐(Scr)、尿素氮(BUN)、尿痠(UA)、內生肌酐清除率(CCr)、Ca、P、全段甲狀徬腺激素(iPTH)的變化;結果:治療組有效率為82.9%,優于對照組的65.7%(P<0.05);治療後治療組BUN水平低于對照組(P<0.05),兩組患者Scr、UA、Ca水平比較差異無統計學意義(P>0.05);兩組患者血清P、iPTH水平低于治療前(P<0.05,P<0.01),治療組優于對照組(P<0.05).結論:補腎健骨方有助于緩解CKD-MBD患者的臨床癥狀,併在降低尿素氮、血燐及甲狀徬腺激素水平、調節鈣燐代謝方麵具有一定的作用.
목적:관찰보신건골방치료만성신장병-광물질화골이상(CKD-MBD)적림상료효.방법:장부합납입표준적70례환자안수궤수자표법분위치료조、대조조,35례.대조조급여상규치료,치료조우상규치료기출상가복보신건골방,료정4주.관찰량조환자적총료효급치료전후혈청기항(Scr)、뇨소담(BUN)、뇨산(UA)、내생기항청제솔(CCr)、Ca、P、전단갑상방선격소(iPTH)적변화;결과:치료조유효솔위82.9%,우우대조조적65.7%(P<0.05);치료후치료조BUN수평저우대조조(P<0.05),량조환자Scr、UA、Ca수평비교차이무통계학의의(P>0.05);량조환자혈청P、iPTH수평저우치료전(P<0.05,P<0.01),치료조우우대조조(P<0.05).결론:보신건골방유조우완해CKD-MBD환자적림상증상,병재강저뇨소담、혈린급갑상방선격소수평、조절개린대사방면구유일정적작용.
Objective:To observe the effect of Bushen Jiangu decoction in the treatment of mineral and bone dis-order chronic kidney disease of ( CKD-MBD) .Methods:A total of 70 patients who met the inclusion criteria were randomly divided into a treatment group and a control group, with 35 cases in each group.The control group was given conventional treatment,and the treatment group was based on the routine treatment plus orally taking Bushen Jiangu decoction,with 4 weeks as a course of treatment.Observe the total effect in two groups according to seram creatinine( Scr) , blood urea nitrogen ( BUN) , uric acid ( UA) , creatinine clearance rate ( CCr) ,Ca, P, intact parathyroid hormone ( iPTH) changes before and after treatment.Results:The effective rate in the treatment group was 82.9%,which was better than 65.7%in the control group(P<0.05);after treatment, BUN in the treatment group was lower than that in the control group ( P <0.05 ) , and the two groups had no statistical significance according to Scr, UA, Ca (P>0.05);the serum P, iPTH levels in two groups were lower than those before treatment (P<0.05,P<0.01),and the treatment group was superior to the control group ( P<0 .05 ) .Conclusion:Bushen Jiangu decoction can relieve the clinical symptoms of pa-tients with CKD-MBD,and it plays a role in reducing blood urea nitrogen, serum phosphorus and parathyroid hormone levels, regulating calcium and phosphorus metabolism.
