中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
59-60,64
,共3页
西酞普兰%抑郁症%白细胞介素-6%脑源性神经生长因子%皮质醇
西酞普蘭%抑鬱癥%白細胞介素-6%腦源性神經生長因子%皮質醇
서태보란%억욱증%백세포개소-6%뇌원성신경생장인자%피질순
citalopram%depressive syndrome%interleukin-6%brain derived neurotrophic factor%cortisol
目的 探究西酞普兰对抑郁症患者血清白细胞介素-6 (interleukin-6, IL-6)、脑源性神经营养因子(brain derived neurotrophic factor,BDNF)以及血浆皮质醇的影响.方法 收集浙江省嘉善县康慈医院门诊抑郁症患者60例,随机分为2组.治疗组31例,采用口服西酞普兰治疗方案,对照组29例采用三环类抗抑郁药丙米嗪治疗方案,比较实验前后2组患者血清中IL-6、BDNF以及血浆皮质醇水平.结果 治疗后2组患者IL-6、皮质醇水平明显下降(P<0.05),BDNF水平升高(P<0.05);与对照组相比,治疗组IL-6、皮质醇水平较低(P<0.05),BDNF水平较高(P<0.05).结论 西酞普兰对抑郁症的疗效显著,其机制可能与降低IL-6与皮质醇水平,升高脑源性神经生长因子有关.
目的 探究西酞普蘭對抑鬱癥患者血清白細胞介素-6 (interleukin-6, IL-6)、腦源性神經營養因子(brain derived neurotrophic factor,BDNF)以及血漿皮質醇的影響.方法 收集浙江省嘉善縣康慈醫院門診抑鬱癥患者60例,隨機分為2組.治療組31例,採用口服西酞普蘭治療方案,對照組29例採用三環類抗抑鬱藥丙米嗪治療方案,比較實驗前後2組患者血清中IL-6、BDNF以及血漿皮質醇水平.結果 治療後2組患者IL-6、皮質醇水平明顯下降(P<0.05),BDNF水平升高(P<0.05);與對照組相比,治療組IL-6、皮質醇水平較低(P<0.05),BDNF水平較高(P<0.05).結論 西酞普蘭對抑鬱癥的療效顯著,其機製可能與降低IL-6與皮質醇水平,升高腦源性神經生長因子有關.
목적 탐구서태보란대억욱증환자혈청백세포개소-6 (interleukin-6, IL-6)、뇌원성신경영양인자(brain derived neurotrophic factor,BDNF)이급혈장피질순적영향.방법 수집절강성가선현강자의원문진억욱증환자60례,수궤분위2조.치료조31례,채용구복서태보란치료방안,대조조29례채용삼배류항억욱약병미진치료방안,비교실험전후2조환자혈청중IL-6、BDNF이급혈장피질순수평.결과 치료후2조환자IL-6、피질순수평명현하강(P<0.05),BDNF수평승고(P<0.05);여대조조상비,치료조IL-6、피질순수평교저(P<0.05),BDNF수평교고(P<0.05).결론 서태보란대억욱증적료효현저,기궤제가능여강저IL-6여피질순수평,승고뇌원성신경생장인자유관.
Objective To explore the effects of citalopram on interleukin-6 (IL-6) and brain derived neurotrophic factor (BDNF) in serum and cortisol in plasma of patients with depression syndrome.Methods 60 patients with depression in Kangci Hospital of Jiashan were randomly divided into two groups.31 cases in experimental group were treated with citalopram, 29 cases in control group were treated with imipramine.Levels of IL-6 and BDNF in serum and cortisol in plasma were compared pre-and post-treatment between two groups.Results Compared with pre-treatment, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05) post-treatment in two groups.Compared with control group, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05)in experimental group.Conclusion Citalopram has good curative effect on depression.The mechanism may be related to the decrease of IL-6 and cortisol levels, and the increase of brain derived neurotrophic factor level.
