中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
48-50
,共3页
江华%刘东斌%梁阔%刘家峰
江華%劉東斌%樑闊%劉傢峰
강화%류동빈%량활%류가봉
复方氨基酸15双肽2注射液%肝癌术%肿瘤标志物%负氮平衡%免疫功能
複方氨基痠15雙肽2註射液%肝癌術%腫瘤標誌物%負氮平衡%免疫功能
복방안기산15쌍태2주사액%간암술%종류표지물%부담평형%면역공능
compound amino acid 15-peptide 2 injection%liver cancer%tumor markers%negative nitrogen balance%immune function
目的 探讨复方氨基酸15双肽2注射液对肝癌术后患者血清中肿瘤标志物水平影响研究.方法 收集收治的原发性肝癌行手术治疗的患者42例,随机分为对照组和实验组,每组各21例,分别给予相应的肠外营养治疗,治疗结束后,对所有患者的血清肿瘤标志物、T淋巴细胞、肝功能及氮平衡相关指标进行检测.结果 治疗后,与对照组比较,实验组患者的血清甲胎蛋白(alpha fetal protein,AFP)、糖链抗原19-9(carbohydrate antigen 19-9,CA19-9)、癌胚抗原(carcino embryonie antigen,CEA)水平较低(P<0.05);实验组患者的血清CD3 +T细胞、CD4 +T细胞及CD4 +/CD8 +比值水平较高,CD8 +T细胞水平较低(P<0.05);实验组患者的血清丙氨酸氨基转移酶(alanine amino transferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、总胆红素(total bilirubin, TBIL)水平较低(P<0.05);实验组患者转为正氮平衡,与对照组比较,差异具有统计学意义(P<0.05).结论 复方氨基酸15双肽2注射液稀释后经外周静脉滴注,能够显著降低肝癌术后患者血清肿瘤标志物水平,提高患者的免疫功能,纠正负氮平衡状态,保护肝功能.
目的 探討複方氨基痠15雙肽2註射液對肝癌術後患者血清中腫瘤標誌物水平影響研究.方法 收集收治的原髮性肝癌行手術治療的患者42例,隨機分為對照組和實驗組,每組各21例,分彆給予相應的腸外營養治療,治療結束後,對所有患者的血清腫瘤標誌物、T淋巴細胞、肝功能及氮平衡相關指標進行檢測.結果 治療後,與對照組比較,實驗組患者的血清甲胎蛋白(alpha fetal protein,AFP)、糖鏈抗原19-9(carbohydrate antigen 19-9,CA19-9)、癌胚抗原(carcino embryonie antigen,CEA)水平較低(P<0.05);實驗組患者的血清CD3 +T細胞、CD4 +T細胞及CD4 +/CD8 +比值水平較高,CD8 +T細胞水平較低(P<0.05);實驗組患者的血清丙氨痠氨基轉移酶(alanine amino transferase,ALT)、天門鼕氨痠氨基轉移酶(aspartate aminotransferase,AST)、總膽紅素(total bilirubin, TBIL)水平較低(P<0.05);實驗組患者轉為正氮平衡,與對照組比較,差異具有統計學意義(P<0.05).結論 複方氨基痠15雙肽2註射液稀釋後經外週靜脈滴註,能夠顯著降低肝癌術後患者血清腫瘤標誌物水平,提高患者的免疫功能,糾正負氮平衡狀態,保護肝功能.
목적 탐토복방안기산15쌍태2주사액대간암술후환자혈청중종류표지물수평영향연구.방법 수집수치적원발성간암행수술치료적환자42례,수궤분위대조조화실험조,매조각21례,분별급여상응적장외영양치료,치료결속후,대소유환자적혈청종류표지물、T림파세포、간공능급담평형상관지표진행검측.결과 치료후,여대조조비교,실험조환자적혈청갑태단백(alpha fetal protein,AFP)、당련항원19-9(carbohydrate antigen 19-9,CA19-9)、암배항원(carcino embryonie antigen,CEA)수평교저(P<0.05);실험조환자적혈청CD3 +T세포、CD4 +T세포급CD4 +/CD8 +비치수평교고,CD8 +T세포수평교저(P<0.05);실험조환자적혈청병안산안기전이매(alanine amino transferase,ALT)、천문동안산안기전이매(aspartate aminotransferase,AST)、총담홍소(total bilirubin, TBIL)수평교저(P<0.05);실험조환자전위정담평형,여대조조비교,차이구유통계학의의(P<0.05).결론 복방안기산15쌍태2주사액희석후경외주정맥적주,능구현저강저간암술후환자혈청종류표지물수평,제고환자적면역공능,규정부담평형상태,보호간공능.
Objective To analysis effect of compound amino acid 15 peptide 2 on levels of tumor markers in serum of postoperative patients with liver cancer.Methods 42 postoperative patients who were diagnosed with liver cancer were collected.All patients were randomly divided into experimental group and control group, 21 cases in each group.The two groups of patients were given the corresponding parenteral nutrition therapy, after treatment, the serum tumor markers, T lymphocytes, liver function and nitrogen balance related indicators in all patients were detected.Results After treatment, compared with control group, the serum alpha fetal protein(AFP),carbohydrate antigen 19-9(CA19-9) and carcino embryonie antigen(CEA) levels were lower in the experimental group (P<0.05); the serum CD3 +T cells, CD4 +T cells and CD4 +/CD8 + ratio levels were lower in the experimental group (P<0.05); the serum alanine amino transferase (ALT), aspartate aminotransferase (AST) and total bilirubin(TBIL) levels were lower in the experimental group (P<0.05); the patients in the experimental group changed to positive nitrogen balance(P<0.05).Conclusion The diluted compound amino acid 15-2 injection for intravenous injection,can significantly reduce the level of serum tumor markers in patients with liver cancer, improve the immune function of patients, correct negative nitrogen balance, protect liver function.
