中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
44-47
,共4页
郑树法%姚培森%黄小芬%余良宏%王伟%康德智
鄭樹法%姚培森%黃小芬%餘良宏%王偉%康德智
정수법%요배삼%황소분%여량굉%왕위%강덕지
丁苯酞注射液%脑血管痉挛%神经特异性烯醇酶%C-反应蛋白%特异性烯醇酶%脂肪酸结合蛋白
丁苯酞註射液%腦血管痙攣%神經特異性烯醇酶%C-反應蛋白%特異性烯醇酶%脂肪痠結閤蛋白
정분태주사액%뇌혈관경련%신경특이성희순매%C-반응단백%특이성희순매%지방산결합단백
butylphthalide injection%aneurysmal subarachnoid hemorrhage%cerebral vasospasm%neuron specific enolase%C-reactive protein%fatty acid binding protein
探讨丁苯酞注射液对动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清神经特异性烯醇酶、C-反应蛋白及脂肪酸结合蛋白水平的影响.方法 收集福建医科大学附属第一医院神经外科收治的动脉瘤性蛛网膜下腔出血术后脑血管痉挛患者90例,分为对照组和实验组,每组各45例,对照组给予尼莫地平和"3H"疗法等常规动脉瘤治疗方法,实验组在对照组的基础上静脉使用丁苯酞注射液.比较患者治疗前后经颅多普勒(transcranial doppler, TCD)血流参数、血清神经特异性烯醇酶(neuron specific enolase,NSE)、脂肪酸结合蛋白(fatty acid binding protein,FABP)、C-反应蛋白(C-reactive protein,CRP)水平.结果 实验组患者与对照组相比大脑中动脉血流痉挛参数明显改善(P<0.05);实验组患者治疗后的血清NSE、CRP、FABP水平较低(P<0.05);实验组患者与对照组比较其脑梗死率较低(P<0.05).结论 丁苯酞注射液能够显著降低动脉瘤性蛛网膜下腔出血脑血管痉挛患者血清NSE、CRP以及FABP水平,改善脑部血流,是治疗动脉瘤性蛛网膜下腔出血脑血管痉挛患者的一种有效的联合疗法.
探討丁苯酞註射液對動脈瘤性蛛網膜下腔齣血腦血管痙攣患者血清神經特異性烯醇酶、C-反應蛋白及脂肪痠結閤蛋白水平的影響.方法 收集福建醫科大學附屬第一醫院神經外科收治的動脈瘤性蛛網膜下腔齣血術後腦血管痙攣患者90例,分為對照組和實驗組,每組各45例,對照組給予尼莫地平和"3H"療法等常規動脈瘤治療方法,實驗組在對照組的基礎上靜脈使用丁苯酞註射液.比較患者治療前後經顱多普勒(transcranial doppler, TCD)血流參數、血清神經特異性烯醇酶(neuron specific enolase,NSE)、脂肪痠結閤蛋白(fatty acid binding protein,FABP)、C-反應蛋白(C-reactive protein,CRP)水平.結果 實驗組患者與對照組相比大腦中動脈血流痙攣參數明顯改善(P<0.05);實驗組患者治療後的血清NSE、CRP、FABP水平較低(P<0.05);實驗組患者與對照組比較其腦梗死率較低(P<0.05).結論 丁苯酞註射液能夠顯著降低動脈瘤性蛛網膜下腔齣血腦血管痙攣患者血清NSE、CRP以及FABP水平,改善腦部血流,是治療動脈瘤性蛛網膜下腔齣血腦血管痙攣患者的一種有效的聯閤療法.
탐토정분태주사액대동맥류성주망막하강출혈뇌혈관경련환자혈청신경특이성희순매、C-반응단백급지방산결합단백수평적영향.방법 수집복건의과대학부속제일의원신경외과수치적동맥류성주망막하강출혈술후뇌혈관경련환자90례,분위대조조화실험조,매조각45례,대조조급여니막지평화"3H"요법등상규동맥류치료방법,실험조재대조조적기출상정맥사용정분태주사액.비교환자치료전후경로다보륵(transcranial doppler, TCD)혈류삼수、혈청신경특이성희순매(neuron specific enolase,NSE)、지방산결합단백(fatty acid binding protein,FABP)、C-반응단백(C-reactive protein,CRP)수평.결과 실험조환자여대조조상비대뇌중동맥혈류경련삼수명현개선(P<0.05);실험조환자치료후적혈청NSE、CRP、FABP수평교저(P<0.05);실험조환자여대조조비교기뇌경사솔교저(P<0.05).결론 정분태주사액능구현저강저동맥류성주망막하강출혈뇌혈관경련환자혈청NSE、CRP이급FABP수평,개선뇌부혈류,시치료동맥류성주망막하강출혈뇌혈관경련환자적일충유효적연합요법.
To investigate influence of butylphthalide injection on serum neuron specific enolase, C-reactive protein and fatty acid binding protein levels in patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage.Methods Ninety patients with cerebral vasospasm were admitted to The First Affiliated Hospital of Fujian Medical University, then the patients were divided into two groups: The control group (45 patients) was treated with nimodipine and triple-H therapy after surgery;in addition to nimodipine and triple-H therapy, butylphthalide injection was administered to the experimental group(45 patients).Transcranial doppler(TCD)was used for the evaluating cerebral artery blood flow velocity, and the serum neuron specific enolase(NSE), C-reactive protein(CRP) and fatty acid binding protein(FABP) levels in patients with cerebral vasospasm were measured. Results The experimental group improved significantly more than the control group, a significant decrease in cerebral blood flow velocity of the middle cerebral artery in the experimental group as measured by TCD (P<0.05).The serum levels of NSE, CRP and FABP in the patients in the experimental group decreased more significantly (P<0.05).And the incidence of cerebral infarction in experimental group was lower than that in control group (P<0.05).Conclusion The serum levels of NSE, CRP and FABP in the patients with cerebral vasospasm following aneurysmal subarachnoid hemorrhage could be significantly reduced by administration of butylphthalide injection, which also could improve cerebral blood supply.Therefore, administration of butylphthalide injection is an effective treatment for cerebral vasospasm.
