中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
68-69,72
,共3页
丙泊酚%七氟烷%肺癌%围术期%炎性反应
丙泊酚%七氟烷%肺癌%圍術期%炎性反應
병박분%칠불완%폐암%위술기%염성반응
propofol%sevoflurane%lung cancer%perioperative period%inflammatory response
目的 探讨丙泊酚全凭静脉麻醉与单纯吸入七氟烷麻醉对肺癌患者围术期炎性反应的影响.方法 收集天津医科大学肿瘤医院麻醉科2014年5 月~2015年4月行肺叶切除术肺癌患者40例,采用随机抽样法分为观察组与对照组各20例.观察组给予丙泊酚全凭静脉麻醉,对照组给予七氟烷单纯吸入麻醉.比较2组麻醉诱导前即刻(T0)、手术开始后1 h(T1)、手术结束即刻(T2)和术后24 h(T3)血清基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子(TNF-α)、白介素-6(IL-6)浓度.结果 2组患者T1、T2、T3时点MMP-9、TNF-α、IL-6浓度与T0时刻相比均升高(P<0.05);与七氟烷组相比,丙泊酚组患者T1、T2、T3时TNF-α、IL-6浓度较低(P<0.05).结论 丙泊酚麻醉可显著降低肺癌患者围术期炎性反应.
目的 探討丙泊酚全憑靜脈痳醉與單純吸入七氟烷痳醉對肺癌患者圍術期炎性反應的影響.方法 收集天津醫科大學腫瘤醫院痳醉科2014年5 月~2015年4月行肺葉切除術肺癌患者40例,採用隨機抽樣法分為觀察組與對照組各20例.觀察組給予丙泊酚全憑靜脈痳醉,對照組給予七氟烷單純吸入痳醉.比較2組痳醉誘導前即刻(T0)、手術開始後1 h(T1)、手術結束即刻(T2)和術後24 h(T3)血清基質金屬蛋白酶-9(MMP-9)、腫瘤壞死因子(TNF-α)、白介素-6(IL-6)濃度.結果 2組患者T1、T2、T3時點MMP-9、TNF-α、IL-6濃度與T0時刻相比均升高(P<0.05);與七氟烷組相比,丙泊酚組患者T1、T2、T3時TNF-α、IL-6濃度較低(P<0.05).結論 丙泊酚痳醉可顯著降低肺癌患者圍術期炎性反應.
목적 탐토병박분전빙정맥마취여단순흡입칠불완마취대폐암환자위술기염성반응적영향.방법 수집천진의과대학종류의원마취과2014년5 월~2015년4월행폐협절제술폐암환자40례,채용수궤추양법분위관찰조여대조조각20례.관찰조급여병박분전빙정맥마취,대조조급여칠불완단순흡입마취.비교2조마취유도전즉각(T0)、수술개시후1 h(T1)、수술결속즉각(T2)화술후24 h(T3)혈청기질금속단백매-9(MMP-9)、종류배사인자(TNF-α)、백개소-6(IL-6)농도.결과 2조환자T1、T2、T3시점MMP-9、TNF-α、IL-6농도여T0시각상비균승고(P<0.05);여칠불완조상비,병박분조환자T1、T2、T3시TNF-α、IL-6농도교저(P<0.05).결론 병박분마취가현저강저폐암환자위술기염성반응.
Objective To investigate effect of propofol total intravenous anesthesia and sevoflurane inhalation anesthesia on perioperative inflammatory response in patients with lung cancer.Methods Forty patients with simple resection of lung cancer were selected in our hospital.They were divided into observation group and control groups according to random sampling method (n=20).Observation group was given propofol total intravenous anesthesia while control group received sevoflurane inhalation anesthesia.The serum concentrations of MMP-9,TNF-α,IL-6 were compared at the T0 (immediately before the induction of anesthesia) , T1 (1 hour after surgery) , T2 (end of the surgery immediately) , T3 (24 hour after surgery) . Results Compared with the T0 period,the serum concentrations of MMP-9,TNF-αand IL-6 at the T1,T2,T3 periods were increased significantly in the both groups(P<0.05);the concentrations of TNF-α, IL-6 were lower significantly in observation group compared with control group (P<0.05) . Conclusion Propofol anesthesia for resection of lung cancer patients can significantly reduce the inflammatory response.
