中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
65-67
,共3页
乙肝肝硬化%中药正肝汤%瘦素%脂联素%胰岛素抵抗
乙肝肝硬化%中藥正肝湯%瘦素%脂聯素%胰島素牴抗
을간간경화%중약정간탕%수소%지련소%이도소저항
hepatitis B cirrhosis%positive liver soup%leptin%adiponectin%insulin resistance
目的 研究中药正肝汤对乙肝肝硬化患者血清瘦素(leptin,LEP)、脂联素(adiponectin,ADP)、水平及胰岛素抵抗(insulin resistance,IR)的影响.方法 选择68例乙肝肝硬化患者按照随机均分为对照组和治疗组.对照组口服易善复和维生素C治疗,治疗组在对照组基础上应用中药正肝汤治疗,治疗疗程为3个月,治疗前、后测定患者血清LEP、 ADP水平及IR指数.结果 治疗前,对照组和治疗组LEP和ADP水平差异无统计学意义.经3个月治疗结束后,对照组LEP和ADP水平与治疗前对比差异无统计学意义;而治疗组LEP和ADP水平对比治疗前有显著下降(P<0.05),且显著低于对照组(P<0.05).治疗前对照组与治疗组FPG、空腹胰岛素水平以及IRS指标的差异无统计学意义.经3个月治疗疗程结束后,对照组FPG、空腹胰岛素水平及IRS指标与治疗前对比差异无统计学意义.治疗组FPG、空腹胰岛素及IRS指标较治疗前均显著下降(P<0.05) ,均显著低于对照组(P<0.05).结论 中药正肝汤治疗乙肝肝硬化能降低血清LEP、ADP水平,并有改善IR指数的作用.
目的 研究中藥正肝湯對乙肝肝硬化患者血清瘦素(leptin,LEP)、脂聯素(adiponectin,ADP)、水平及胰島素牴抗(insulin resistance,IR)的影響.方法 選擇68例乙肝肝硬化患者按照隨機均分為對照組和治療組.對照組口服易善複和維生素C治療,治療組在對照組基礎上應用中藥正肝湯治療,治療療程為3箇月,治療前、後測定患者血清LEP、 ADP水平及IR指數.結果 治療前,對照組和治療組LEP和ADP水平差異無統計學意義.經3箇月治療結束後,對照組LEP和ADP水平與治療前對比差異無統計學意義;而治療組LEP和ADP水平對比治療前有顯著下降(P<0.05),且顯著低于對照組(P<0.05).治療前對照組與治療組FPG、空腹胰島素水平以及IRS指標的差異無統計學意義.經3箇月治療療程結束後,對照組FPG、空腹胰島素水平及IRS指標與治療前對比差異無統計學意義.治療組FPG、空腹胰島素及IRS指標較治療前均顯著下降(P<0.05) ,均顯著低于對照組(P<0.05).結論 中藥正肝湯治療乙肝肝硬化能降低血清LEP、ADP水平,併有改善IR指數的作用.
목적 연구중약정간탕대을간간경화환자혈청수소(leptin,LEP)、지련소(adiponectin,ADP)、수평급이도소저항(insulin resistance,IR)적영향.방법 선택68례을간간경화환자안조수궤균분위대조조화치료조.대조조구복역선복화유생소C치료,치료조재대조조기출상응용중약정간탕치료,치료료정위3개월,치료전、후측정환자혈청LEP、 ADP수평급IR지수.결과 치료전,대조조화치료조LEP화ADP수평차이무통계학의의.경3개월치료결속후,대조조LEP화ADP수평여치료전대비차이무통계학의의;이치료조LEP화ADP수평대비치료전유현저하강(P<0.05),차현저저우대조조(P<0.05).치료전대조조여치료조FPG、공복이도소수평이급IRS지표적차이무통계학의의.경3개월치료료정결속후,대조조FPG、공복이도소수평급IRS지표여치료전대비차이무통계학의의.치료조FPG、공복이도소급IRS지표교치료전균현저하강(P<0.05) ,균현저저우대조조(P<0.05).결론 중약정간탕치료을간간경화능강저혈청LEP、ADP수평,병유개선IR지수적작용.
Objective To study effect of positive liver soup on serum leptin (LEP), adiponectin (ADP) and insulin resistance (IR) in patients with hepatitis B cirrhosis.Methods 68 cases of hepatitis B patients with cirrhosis according to randomized divided into the control group (34 cases) and treatment group (34 cases).Oral treatment administered to the control group (Inosine Tablets and vitamin C),treatment group in the control group based on liver soup treatment, treatment for 3 months, serum leptin (LEP),adiponectin (ADP) and insulin resistance (IR) index before and after treatment were detected.Results Before treatment, there was no significant difference between ADP and LEP in the control group and the treatment group.After 3 months of treatment, there was no significant difference between ADP and LEP level in control group, while the level of ADP and LEP in treatment group were significantly decreased (P<0.05), and were significantly lower than that in control group (P<0.05).There was no significant difference in FPG, fasting insulin level and IRS index between the control group and the treatment group before treatment.After 3 months of treatment, the control group FPG, fasting insulin level and IRS index were not significantly different.FPG, fasting insulin and IRS index in the treatment group were significantly decreased (P<0.05), and were significantly lower than those in the control group (P<0.05).Conclusion Positive liver soup can reduce serum LEP, ADP level, and improve IR in treatment of hepatitis B liver cirrhosis.
