中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
61-64
,共4页
慢性心衰%炙甘草汤%真武汤%老年%基质金属蛋白酶-9%基质金属蛋白酶抑制剂-1%心肌酶
慢性心衰%炙甘草湯%真武湯%老年%基質金屬蛋白酶-9%基質金屬蛋白酶抑製劑-1%心肌酶
만성심쇠%자감초탕%진무탕%노년%기질금속단백매-9%기질금속단백매억제제-1%심기매
chronic heart failure%Zhenwu Decoction%Zhigancao Decoction%aged patients%matrix metalloproteinase-9%tissue inhibitor of metalloproteinase-1%myocardial enzymes
目的 比较炙甘草汤与真武汤对老年慢性心衰患者血流动力学、基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)、基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)及心肌酶谱的影响差异.方法 选取石河子大学医学院第一附属医院收治的老年慢性心衰患者40例,随机分为炙甘草汤组(n=20)与真武汤组(n=20).2组患者均给予常规治疗,在常规治疗基础上按照不同分组给予相应药物治疗,治疗2周为1个疗程,共治疗2个疗程.治疗结束后,比较2组患者的血流动力学、MMP-9、TIMP-1及心肌酶谱指标.结果 经治疗,2组患者血流动力学均改善,炙甘草汤组血流动力学各项指标改善优于真武汤组(P<0.05).炙甘草汤组血清MMP-9及MMP-9/TIMP-1较真武汤组降低(P<0.05),炙甘草汤组血清TIMP-1较真武汤组增高(P<0.05).治疗后2组心肌酶指标均降低,炙甘草汤各指标较真武汤组显著降低(P<0.05).结论 炙甘草汤能够明显改善老年慢性心力衰竭症状,疗效优于真武汤,对临床具有指导意义.
目的 比較炙甘草湯與真武湯對老年慢性心衰患者血流動力學、基質金屬蛋白酶-9(matrix metalloproteinase-9,MMP-9)、基質金屬蛋白酶抑製劑-1(tissue inhibitor of metalloproteinase-1,TIMP-1)及心肌酶譜的影響差異.方法 選取石河子大學醫學院第一附屬醫院收治的老年慢性心衰患者40例,隨機分為炙甘草湯組(n=20)與真武湯組(n=20).2組患者均給予常規治療,在常規治療基礎上按照不同分組給予相應藥物治療,治療2週為1箇療程,共治療2箇療程.治療結束後,比較2組患者的血流動力學、MMP-9、TIMP-1及心肌酶譜指標.結果 經治療,2組患者血流動力學均改善,炙甘草湯組血流動力學各項指標改善優于真武湯組(P<0.05).炙甘草湯組血清MMP-9及MMP-9/TIMP-1較真武湯組降低(P<0.05),炙甘草湯組血清TIMP-1較真武湯組增高(P<0.05).治療後2組心肌酶指標均降低,炙甘草湯各指標較真武湯組顯著降低(P<0.05).結論 炙甘草湯能夠明顯改善老年慢性心力衰竭癥狀,療效優于真武湯,對臨床具有指導意義.
목적 비교자감초탕여진무탕대노년만성심쇠환자혈류동역학、기질금속단백매-9(matrix metalloproteinase-9,MMP-9)、기질금속단백매억제제-1(tissue inhibitor of metalloproteinase-1,TIMP-1)급심기매보적영향차이.방법 선취석하자대학의학원제일부속의원수치적노년만성심쇠환자40례,수궤분위자감초탕조(n=20)여진무탕조(n=20).2조환자균급여상규치료,재상규치료기출상안조불동분조급여상응약물치료,치료2주위1개료정,공치료2개료정.치료결속후,비교2조환자적혈류동역학、MMP-9、TIMP-1급심기매보지표.결과 경치료,2조환자혈류동역학균개선,자감초탕조혈류동역학각항지표개선우우진무탕조(P<0.05).자감초탕조혈청MMP-9급MMP-9/TIMP-1교진무탕조강저(P<0.05),자감초탕조혈청TIMP-1교진무탕조증고(P<0.05).치료후2조심기매지표균강저,자감초탕각지표교진무탕조현저강저(P<0.05).결론 자감초탕능구명현개선노년만성심력쇠갈증상,료효우우진무탕,대림상구유지도의의.
Objective To compare the effect of Zhigancao Decoction and Zhenwu Decoction on hemodynamics, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) and myocardial enzyme of elderly patients with chronic heart failure.Methods 40 elderly patients with chronic heart failure in the first affiliated hospital of the medical college, Shihezi university were selected and randomly divided into Zhigancao Decoction group (n=20) and Zhenwu Decoction group (n =20) .The both of two groups were given conventional treatment, then were treated with respective drug according to different groups with two courses, one course of two weeks.The hemodynamic, MMP-9, TIMP-1 and myocardial enzyme spectrum indexes of two groups were compared post-treatment.Results After treatment, the indexes of hemodynamics in two groups were improved, hemodynamic indexes of Zhigancao Decoction recovered better than those of Zhenwu Decoction (P<0.05) .The serum MMP-9, MMP-9/TIMP-1 of Zhigancao Decoction group were lower and TIMP-1 was higher than those of Zhenwu Decoction group (P<0.05).The myocardial enzyme indexes in both groups were lower post-treatment, and the above indexes in Zhigancao Decoction were lower than those in Zhenwu Decoction group (P<0.05) . Conclusion Zhigancao Decoction could obviously improve the symptoms of chronic heart failure in elderly patients, which has the guiding significant in the clinical treatment.
