中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
22-24
,共3页
逍遥丸%盆腔炎%超氧化物歧化酶%丙二醛%白介素
逍遙汍%盆腔炎%超氧化物歧化酶%丙二醛%白介素
소요환%분강염%초양화물기화매%병이철%백개소
Xiaoyao pill%pelvic inflammation%superoxide dismutase%malondialdehyde%interleukin
目的 探讨逍遥丸治疗对盆腔炎患者血清超氧化物歧化酶(superoxide dismutase, SOD)、丙二醛(malondialdehyde, MDA)及白介素族指标及临床疗效的影响.方法 选取浙江中医药大学第一临床医学院妇科确诊为盆腔炎患者75例,采用随机数字表法随机分为实验组和对照组,对照组37例,接受常规抗炎联合千金片治疗;实验组38例,接受常规抗炎联合逍遥丸治疗,共治疗14 d.比较2组患者治疗前后血清SOD、MDA及白介素族指标变化,以及2组有效率及不良反应发生率.结果 与对照组治疗后比较,实验组患者血清中SOD水平明显升高(P<0.05) , MDA水平明显降低(P<0.05);实验组血清IL-1、IL-8 水平明显降低(P<0.05),IL-4、IL-10水平明显升高(P<0.05);实验组的总有效率明显高于对照组(P<0.05),不良反应较轻微.结论 逍遥丸对盆腔炎患者具有较好的疗效,其机制可能与升高血清SOD、IL-4、IL-10水平,降低MDA、IL-1、IL-8水平有关.
目的 探討逍遙汍治療對盆腔炎患者血清超氧化物歧化酶(superoxide dismutase, SOD)、丙二醛(malondialdehyde, MDA)及白介素族指標及臨床療效的影響.方法 選取浙江中醫藥大學第一臨床醫學院婦科確診為盆腔炎患者75例,採用隨機數字錶法隨機分為實驗組和對照組,對照組37例,接受常規抗炎聯閤韆金片治療;實驗組38例,接受常規抗炎聯閤逍遙汍治療,共治療14 d.比較2組患者治療前後血清SOD、MDA及白介素族指標變化,以及2組有效率及不良反應髮生率.結果 與對照組治療後比較,實驗組患者血清中SOD水平明顯升高(P<0.05) , MDA水平明顯降低(P<0.05);實驗組血清IL-1、IL-8 水平明顯降低(P<0.05),IL-4、IL-10水平明顯升高(P<0.05);實驗組的總有效率明顯高于對照組(P<0.05),不良反應較輕微.結論 逍遙汍對盆腔炎患者具有較好的療效,其機製可能與升高血清SOD、IL-4、IL-10水平,降低MDA、IL-1、IL-8水平有關.
목적 탐토소요환치료대분강염환자혈청초양화물기화매(superoxide dismutase, SOD)、병이철(malondialdehyde, MDA)급백개소족지표급림상료효적영향.방법 선취절강중의약대학제일림상의학원부과학진위분강염환자75례,채용수궤수자표법수궤분위실험조화대조조,대조조37례,접수상규항염연합천금편치료;실험조38례,접수상규항염연합소요환치료,공치료14 d.비교2조환자치료전후혈청SOD、MDA급백개소족지표변화,이급2조유효솔급불량반응발생솔.결과 여대조조치료후비교,실험조환자혈청중SOD수평명현승고(P<0.05) , MDA수평명현강저(P<0.05);실험조혈청IL-1、IL-8 수평명현강저(P<0.05),IL-4、IL-10수평명현승고(P<0.05);실험조적총유효솔명현고우대조조(P<0.05),불량반응교경미.결론 소요환대분강염환자구유교호적료효,기궤제가능여승고혈청SOD、IL-4、IL-10수평,강저MDA、IL-1、IL-8수평유관.
Objective To investigate effect of Xiaoyao pill on superoxide dismutase (SOD), malondialdehyde (MDA), interleukin family and clinical efficacy in patients with pelvic inflammation.Methods 75 cases with pelvic inflammation were selected and divided into experimental group and control group randomly according to random number table method.37 cases in control group were treated with conventional anti-inflammatory and Qianjin pill, 38 cases in experimental group were treated with conventional anti-inflammatory and Xiaoyao pill, 14 days for a course.SOD, MDA and interleukin family were compared and the effective rate and adverse reaction rate were compared.Results Compared with control group post-treatment, SOD in serum in experimental group was higher(P<0.05),MDA in serum was lower(P<0.05);IL-1 and IL-8 were lower(P<0.05);IL-4 and IL-10 were higher(P<0.05).The total efficiency of experimental group was significantly higher than that of control group, the adverse reactions were lower (P<0.05).Conclusion Xiaoyao pill has good curative effect on the patients with pelvic inflammatory disease,the mechanism may be related to the elevation of serum SOD,IL-4, IL-10 levels and reduce the levels of MDA,IL-1,IL-8.
