中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
105-107
,共3页
缓释茶碱%剂量%小儿哮喘%前白蛋白%C-反应蛋白%白细胞
緩釋茶堿%劑量%小兒哮喘%前白蛋白%C-反應蛋白%白細胞
완석다감%제량%소인효천%전백단백%C-반응단백%백세포
sustained release theophylline%dose%children asthma%prealbumin%C-reactive protein%white blood cell
目的 探讨不同剂量缓释茶碱对小儿哮喘前白蛋白(prealbumin,PA)、C-反应蛋白(C-reaction protein,CRP)及白细胞计数(white blood cell cout,WBC)的影响.方法 收集杭州余杭区第一人民医院儿科收治的哮喘急性发作期的患儿58例,随机分为高剂量组和低剂量组,每组各29例,在常规治疗基础上,高剂量组患儿给予高剂量茶碱缓释片口服治疗,5 mg/kg,每8 h一次口服.低剂量组给予小剂量茶碱缓释片口服治疗2 mg/kg,每8 h一次口服.2组患儿均治疗2周.治疗结束后,对所有患儿的血清前白蛋白、C-反应蛋白水平及静脉血白细胞计数水平相关指标进行检测.结果 与高剂量组治疗后比较,低剂量组患儿血清PA水平较高(P<0.05);低剂量组患儿的血清CRP水平较低(P<0.05);低剂量组患儿的静脉血静脉血WBC、中性粒细胞百分比、嗜酸性粒细胞百分比较低(P<0.05).结论 低剂量缓释茶碱与高剂量相比,能够更显著降低哮喘患儿的血清CRP水平及静脉血WBC、中性粒细胞百分比、嗜酸性粒细胞百分比,提高血清PA水平,减轻患儿炎症状态.
目的 探討不同劑量緩釋茶堿對小兒哮喘前白蛋白(prealbumin,PA)、C-反應蛋白(C-reaction protein,CRP)及白細胞計數(white blood cell cout,WBC)的影響.方法 收集杭州餘杭區第一人民醫院兒科收治的哮喘急性髮作期的患兒58例,隨機分為高劑量組和低劑量組,每組各29例,在常規治療基礎上,高劑量組患兒給予高劑量茶堿緩釋片口服治療,5 mg/kg,每8 h一次口服.低劑量組給予小劑量茶堿緩釋片口服治療2 mg/kg,每8 h一次口服.2組患兒均治療2週.治療結束後,對所有患兒的血清前白蛋白、C-反應蛋白水平及靜脈血白細胞計數水平相關指標進行檢測.結果 與高劑量組治療後比較,低劑量組患兒血清PA水平較高(P<0.05);低劑量組患兒的血清CRP水平較低(P<0.05);低劑量組患兒的靜脈血靜脈血WBC、中性粒細胞百分比、嗜痠性粒細胞百分比較低(P<0.05).結論 低劑量緩釋茶堿與高劑量相比,能夠更顯著降低哮喘患兒的血清CRP水平及靜脈血WBC、中性粒細胞百分比、嗜痠性粒細胞百分比,提高血清PA水平,減輕患兒炎癥狀態.
목적 탐토불동제량완석다감대소인효천전백단백(prealbumin,PA)、C-반응단백(C-reaction protein,CRP)급백세포계수(white blood cell cout,WBC)적영향.방법 수집항주여항구제일인민의원인과수치적효천급성발작기적환인58례,수궤분위고제량조화저제량조,매조각29례,재상규치료기출상,고제량조환인급여고제량다감완석편구복치료,5 mg/kg,매8 h일차구복.저제량조급여소제량다감완석편구복치료2 mg/kg,매8 h일차구복.2조환인균치료2주.치료결속후,대소유환인적혈청전백단백、C-반응단백수평급정맥혈백세포계수수평상관지표진행검측.결과 여고제량조치료후비교,저제량조환인혈청PA수평교고(P<0.05);저제량조환인적혈청CRP수평교저(P<0.05);저제량조환인적정맥혈정맥혈WBC、중성립세포백분비、기산성립세포백분비교저(P<0.05).결론 저제량완석다감여고제량상비,능구경현저강저효천환인적혈청CRP수평급정맥혈WBC、중성립세포백분비、기산성립세포백분비,제고혈청PA수평,감경환인염증상태.
Objective To analyse effect of different dose of sustained-release theophyline on prealbumin, C-reactive protein and white blood cell count in patients with pediatric asthma.Methods 58 children with acute asthma attack in our hospital were collected.All children were randomly divided into high dose group and low dose group,29 cases in each group.On the basis of conventional treatment, high dose group were treated with high dose theophylline sustained release tablets 5 mg/kg, one times per eight hours,orally,and low dose group was treated with low dose theophylline sustained release tablets,2 mg/kg, one times per eight hours,orally.Two groups were treatment for two weeks.After the treatment, the serum levels of pre albumin, C-reactive protein and veinal blood level of white blood cell count were detected in all children.Results Compared with high dose group post-treatment, the serum level PA was higher in low dose group (P<0.05);the serum level of CRP was lower in low dose group (P<0.05);the veinal blood level of WBC, percentage of neutrophils and percentage of eosinophils was lower in low dose group (P<0.05) .Conclusion Compared with high dose of sustained-release theophyline,the low dose of sustained-release theophyline can significantly reduce the serum CRP level and veinal blood level of WBC, percentage of neutrophils and percentage of eosinophils, improve serum PA level in patients with pediatric asthma, reduce inflammation in patients.
