中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
90-92
,共3页
谷氨酰胺%胃癌%术后%营养指标%癌胚抗原%甲胎蛋白%免疫功能
穀氨酰胺%胃癌%術後%營養指標%癌胚抗原%甲胎蛋白%免疫功能
곡안선알%위암%술후%영양지표%암배항원%갑태단백%면역공능
glutamine%gastric cancer%postoperative%nutritional parameters%carcino embryonie antigen%alpha fetal protein%immune function
目的 探讨谷氨酰胺对胃癌术后患者血清癌胚抗原(carcino embryonie antigen,CEA)、甲胎蛋白(alpha fetal protein, AFP)及T细胞免疫功能的影响.方法 收集浙江省义乌市中心医院收治的胃癌根治术后患者52例,根据用药不同分为对照组和实验组,每组各26例,对照组采用常规营养治疗,实验组在对照组基础上加用丙氨酰谷氨酰胺注射液.治疗结束后,对所有患者的血清营养指标、CEA、AFP、CD4 +T、CD8 +T水平进行检测.结果 治疗后与对照组相比,实验组患者血清白蛋白(albumin,ALB)、前白蛋白(pre-albumin,PA)水平较高(P<0.05),CEA、AFP水平较低(P<0.05),血清CD4 +T、CD4 +T/CD8 +T水平较高(P<0.05),CD8 +T水平较低(P<0.05).结论 谷氨酰胺能够显著改善胃癌术后患者临床症状,其机制与升高血清ALB、PA水平,降低CEA、AFP水平,改善其免疫功能有关.
目的 探討穀氨酰胺對胃癌術後患者血清癌胚抗原(carcino embryonie antigen,CEA)、甲胎蛋白(alpha fetal protein, AFP)及T細胞免疫功能的影響.方法 收集浙江省義烏市中心醫院收治的胃癌根治術後患者52例,根據用藥不同分為對照組和實驗組,每組各26例,對照組採用常規營養治療,實驗組在對照組基礎上加用丙氨酰穀氨酰胺註射液.治療結束後,對所有患者的血清營養指標、CEA、AFP、CD4 +T、CD8 +T水平進行檢測.結果 治療後與對照組相比,實驗組患者血清白蛋白(albumin,ALB)、前白蛋白(pre-albumin,PA)水平較高(P<0.05),CEA、AFP水平較低(P<0.05),血清CD4 +T、CD4 +T/CD8 +T水平較高(P<0.05),CD8 +T水平較低(P<0.05).結論 穀氨酰胺能夠顯著改善胃癌術後患者臨床癥狀,其機製與升高血清ALB、PA水平,降低CEA、AFP水平,改善其免疫功能有關.
목적 탐토곡안선알대위암술후환자혈청암배항원(carcino embryonie antigen,CEA)、갑태단백(alpha fetal protein, AFP)급T세포면역공능적영향.방법 수집절강성의오시중심의원수치적위암근치술후환자52례,근거용약불동분위대조조화실험조,매조각26례,대조조채용상규영양치료,실험조재대조조기출상가용병안선곡안선알주사액.치료결속후,대소유환자적혈청영양지표、CEA、AFP、CD4 +T、CD8 +T수평진행검측.결과 치료후여대조조상비,실험조환자혈청백단백(albumin,ALB)、전백단백(pre-albumin,PA)수평교고(P<0.05),CEA、AFP수평교저(P<0.05),혈청CD4 +T、CD4 +T/CD8 +T수평교고(P<0.05),CD8 +T수평교저(P<0.05).결론 곡안선알능구현저개선위암술후환자림상증상,기궤제여승고혈청ALB、PA수평,강저CEA、AFP수평,개선기면역공능유관.
Objective To investigate the effect of glutamine on the serum carcino embryonie antigen (CEA) , alpha fetal protein (AFP) and T cell immune function in postoperative patients with gastric cancer.Methods 52 postoperative patients with gastric cancer from Yiwu Central Hospital were selected and randomly divided into control group and experimenal group, 26 cases in each group.The control group received routine nutritional therapy, and experimental group received alanyl -glutamine injection on the basis of control group.The serum nutritional parameters, CEA, AFP, CD4 +T, CD8 +T levels were compared post-treatment.Results Compared with control group post-treatment, the serum albumin (ALB) and pre-albumin (PA) levels were higher (P<0.05), the CEA and AFP levels were lower (P<0.05),the serum levels of CD4 +T and CD4 +T/CD8 +T were higher (P<0.05),CD8 +T level were lower (P<0.05).Conclusion Glutamine could significantly improve the clinical symptoms of patients with gastric cancer after surgery,and it is speculated that the mechanism may be the increase of serum ALB, PA levels, the decrease of CEA, AFP levels and the improvement of immune function.
