CAJ | 학술논문

缺血性脑血管病(ischemic cerebrovascular disease,ICVD)是脑部主要动脉的血流暂时或永久的减少引起脑短暂的、突发的、可逆性神经功能障碍.及时恢复脑组织的血液供应是挽救患者生命的最主要办法,但恢复血液灌注的同时又给脑组织器官等带来了新的损伤,这就是脑缺血再灌注损伤(cerebral ischemia reperfusion injury,CIRI).如何建立一种理想的、高效的、易操作的脑缺血再灌注损伤动物模型来模拟临床进行研究,以及近年来科研工作者们如何对此模型进行改良创新,本文就以上内容进行了综述.
결혈성뇌혈관병(ischemic cerebrovascular disease,ICVD)시뇌부주요동맥적혈류잠시혹영구적감소인기뇌단잠적、돌발적、가역성신경공능장애.급시회복뇌조직적혈액공응시만구환자생명적최주요판법,단회복혈액관주적동시우급뇌조직기관등대래료신적손상,저취시뇌결혈재관주손상(cerebral ischemia reperfusion injury,CIRI).여하건립일충이상적、고효적、역조작적뇌결혈재관주손상동물모형래모의림상진행연구,이급근년래과연공작자문여하대차모형진행개량창신,본문취이상내용진행료종술.
Ischemic cerebrovascular disease(ICVD) is temporary or permanent reduction of blood flow of the main arteries of the brain caused by cerebral transient,sudden,reversible neurological dysfunction.Timely recovery of blood supply to the brain is the most important way to save the patient's life,but at the same time gave restore blood perfusion brain tissue organs brought new damage,which is cerebeal ischemia reperfusion injury(CIRI).How to build an ideal,efficient,easy to operate brain ischemia-reperfusion injury in animal models to simulate the clinical study,and how to improve and innovate this model by researchers in recent years were reviewed in this article.