CAJ | 학술논문

目的选取奥美拉唑含量变化较小的调配方法,探寻超说明书用药的合理性.方法 HPLC测定不同调配方法在不同时间点时注射用奥美拉唑钠的含量变化,比较不同调配方法对奥美拉唑钠含量影响.结果选用10 mL 0.9%氯化钠注射液作为溶媒所调配药物溶液稳定性较高,奥美拉唑含量变化较小.结论药品调配方法会影响药物使用的安全性及有效性,也属于合理用药讨论范畴;超说明书给药情况不能全部归为不合理用药,应结合具体文献资料及实际医疗环境而决定.
목적 선취오미랍서함량변화교소적조배방법,탐심초설명서용약적합이성.방법 HPLC측정불동조배방법재불동시간점시주사용오미랍서납적함량변화,비교불동조배방법대오미랍서납함량영향.결과 선용10 mL 0.9%록화납주사액작위용매소조배약물용액은정성교고,오미랍서함량변화교소.결론 약품조배방법회영향약물사용적안전성급유효성,야속우합리용약토론범주;초설명서급약정황불능전부귀위불합리용약,응결합구체문헌자료급실제의료배경이결정.
Objective To select omeprazole content changes smaller with dispensing method and to seek for rationality of off-label uses.Methods To measure content change of omeprazole sodium for injection mixed by different subscriptions at different time through HPLC, and compared effect of different dispensing methods on content of omeprazole sodium for injection.Results 10 mL 0.9%sodium chloride injection was chosed as dissolvent,the change of omeprazole sodium for injection content would be minor, and stability of drug solution was superior.Conclusion Dispensing methods of drug impact on its'security and validity, which is part of discuss category about medicine rational use as well.Off-label uses could not vest in unreasonable use, which should contingent on specific document,data and actual environment of medical treatment.