中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
96-98
,共3页
叶酸%辛复宁%宫颈癌%C反应蛋白%肝细胞生长因子%白细胞介素-2%肿瘤坏死因子-α
葉痠%辛複寧%宮頸癌%C反應蛋白%肝細胞生長因子%白細胞介素-2%腫瘤壞死因子-α
협산%신복저%궁경암%C반응단백%간세포생장인자%백세포개소-2%종류배사인자-α
folic acid%Xin Funing%cervical cancer%C reactive protein%hepatocyte growth factor%interleukin-2%tumor necrosis factor-α
目的 探讨叶酸联合辛复宁对人乳头瘤病毒感染宫颈癌患者血清C反应蛋白(C reactive protein,CRP)、肝细胞生长因子(hepatocyte growth factor,HGF)、白细胞介素-2(interleukin-2,IL-2)及肿瘤坏死因子-α(tuumor necrosis factor-α,TNF-α)水平的影响.方法 选取宫颈癌患者80例,随机分为对照组40例,予常规化疗方案;实验组40例,在常规化疗的基础上加用叶酸及辛复宁,1周为一个疗程,治疗2个疗程.比较2组患者治疗前后CRP、HGF、IL-2、TNF-α及T淋巴细胞亚群的变化.结果 与对照组比较,实验组患者血清CRP、HGF及TNF-α水平较低(P<0.05),IL-2水平较高(P<0.05),实验组CD4 +及CD4 +/CD8 +水平较高(P<0.05), CD8 +水平较低(P<0.05),临床总有效率较高(P<0.05).结论 叶酸联合辛复宁对宫颈癌患者治疗具有重要意义,推测其机制可能为降低人乳头瘤病毒感染宫颈癌患者血清CRP、HGF水平,升高IL-2水平,调节免疫细胞因子.
目的 探討葉痠聯閤辛複寧對人乳頭瘤病毒感染宮頸癌患者血清C反應蛋白(C reactive protein,CRP)、肝細胞生長因子(hepatocyte growth factor,HGF)、白細胞介素-2(interleukin-2,IL-2)及腫瘤壞死因子-α(tuumor necrosis factor-α,TNF-α)水平的影響.方法 選取宮頸癌患者80例,隨機分為對照組40例,予常規化療方案;實驗組40例,在常規化療的基礎上加用葉痠及辛複寧,1週為一箇療程,治療2箇療程.比較2組患者治療前後CRP、HGF、IL-2、TNF-α及T淋巴細胞亞群的變化.結果 與對照組比較,實驗組患者血清CRP、HGF及TNF-α水平較低(P<0.05),IL-2水平較高(P<0.05),實驗組CD4 +及CD4 +/CD8 +水平較高(P<0.05), CD8 +水平較低(P<0.05),臨床總有效率較高(P<0.05).結論 葉痠聯閤辛複寧對宮頸癌患者治療具有重要意義,推測其機製可能為降低人乳頭瘤病毒感染宮頸癌患者血清CRP、HGF水平,升高IL-2水平,調節免疫細胞因子.
목적 탐토협산연합신복저대인유두류병독감염궁경암환자혈청C반응단백(C reactive protein,CRP)、간세포생장인자(hepatocyte growth factor,HGF)、백세포개소-2(interleukin-2,IL-2)급종류배사인자-α(tuumor necrosis factor-α,TNF-α)수평적영향.방법 선취궁경암환자80례,수궤분위대조조40례,여상규화료방안;실험조40례,재상규화료적기출상가용협산급신복저,1주위일개료정,치료2개료정.비교2조환자치료전후CRP、HGF、IL-2、TNF-α급T림파세포아군적변화.결과 여대조조비교,실험조환자혈청CRP、HGF급TNF-α수평교저(P<0.05),IL-2수평교고(P<0.05),실험조CD4 +급CD4 +/CD8 +수평교고(P<0.05), CD8 +수평교저(P<0.05),림상총유효솔교고(P<0.05).결론 협산연합신복저대궁경암환자치료구유중요의의,추측기궤제가능위강저인유두류병독감염궁경암환자혈청CRP、HGF수평,승고IL-2수평,조절면역세포인자.
Objective To investigate effect of folic acid combined with xin funing on CRP, HGF, IL-2,TNF-αof patients with cervical cancer caused by human papillomavirus.Methods 80 cases of cervical cancer patients were randomly divided into control group, 40 cases in the control group were given conventional chemotherapy, 40 cases in the experimental group were on the base of the control with folic acid combined with xin funing.CRP, HGF, TNF-α, IL-2 and T lymphocyte subsets were compared before and after the treatment.Results Compared with the control group, the serum CRP, HGF and TNF-αof the experiment group were lower(P<0.05), IL-2 levels was higher (P<0.05), CD4 +and CD4 +/CD8 +level were higher(P<0.05), level of CD8 +was lower(P<0.05) and the clinical effective rate were higher(P<0.05).Conclusion Folic acid combined with Xin Funing has important significance for the treatment of patients with cervical cancer.It is speculated that the mechanism may be to reduce the level of serum CRP and HGF in patients with cervical cancer, and to increase the level of IL-2, and to regulate immune cells.
