中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
Chinese Journal of Biochemical Pharmaceutics
2015年
10期
93-95
,共3页
低分子肝素%华法林%颅内静脉窦%血栓%疗效
低分子肝素%華法林%顱內靜脈竇%血栓%療效
저분자간소%화법림%로내정맥두%혈전%료효
low molecular weight heparin%warfarin%intracranial venous sinus%blood clots%curative effect
目的 探讨低分子肝素(low molecular weight heparin,LMWH)联合华法林早期抗凝治疗颅内静脉窦血栓的疗效.方法 对新疆自治区人民医院2010年1月~2014年12月收治的80例颅内静脉窦血栓患者进行回顾性分析.观察组37例,采用LMWH联合华法林治疗,对照组43例,采用华法林治疗,比较2组的临床疗效差异.结果 观察组患者的有效率为91.89%,显著高于对照组的67.44%(P<0.05).观察组患者颅内静脉窦再通率为89.19%,显著高于对照组的67.29%(P<0.05).2组患者治疗后凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)及活化部分凝血活酶时间(activated partial thromboplastin time,APTT)较治疗前增加,纤维蛋白原(fibrinogen,FBG)较治疗前减少(P<0.05),且观察组PT与APTT显著高于对照组,FBG显著低于对照组(P<0.05).结论 低分子肝素联合华法林早期抗凝治疗颅内静脉窦血栓的疗效较单用华法林治疗更好.
目的 探討低分子肝素(low molecular weight heparin,LMWH)聯閤華法林早期抗凝治療顱內靜脈竇血栓的療效.方法 對新疆自治區人民醫院2010年1月~2014年12月收治的80例顱內靜脈竇血栓患者進行迴顧性分析.觀察組37例,採用LMWH聯閤華法林治療,對照組43例,採用華法林治療,比較2組的臨床療效差異.結果 觀察組患者的有效率為91.89%,顯著高于對照組的67.44%(P<0.05).觀察組患者顱內靜脈竇再通率為89.19%,顯著高于對照組的67.29%(P<0.05).2組患者治療後凝血酶原時間(prothrombin time,PT)、凝血酶時間(thrombin time,TT)及活化部分凝血活酶時間(activated partial thromboplastin time,APTT)較治療前增加,纖維蛋白原(fibrinogen,FBG)較治療前減少(P<0.05),且觀察組PT與APTT顯著高于對照組,FBG顯著低于對照組(P<0.05).結論 低分子肝素聯閤華法林早期抗凝治療顱內靜脈竇血栓的療效較單用華法林治療更好.
목적 탐토저분자간소(low molecular weight heparin,LMWH)연합화법림조기항응치료로내정맥두혈전적료효.방법 대신강자치구인민의원2010년1월~2014년12월수치적80례로내정맥두혈전환자진행회고성분석.관찰조37례,채용LMWH연합화법림치료,대조조43례,채용화법림치료,비교2조적림상료효차이.결과 관찰조환자적유효솔위91.89%,현저고우대조조적67.44%(P<0.05).관찰조환자로내정맥두재통솔위89.19%,현저고우대조조적67.29%(P<0.05).2조환자치료후응혈매원시간(prothrombin time,PT)、응혈매시간(thrombin time,TT)급활화부분응혈활매시간(activated partial thromboplastin time,APTT)교치료전증가,섬유단백원(fibrinogen,FBG)교치료전감소(P<0.05),차관찰조PT여APTT현저고우대조조,FBG현저저우대조조(P<0.05).결론 저분자간소연합화법림조기항응치료로내정맥두혈전적료효교단용화법림치료경호.
Objective To explore the anticoagulation effect of low molecular weight heparin (LMWH) combination with warfarin at the early stage at the treatment of intracranial venous sinus thrombosis.Methods 80 cases of intracranial venous sinus thrombosis patients in people's hospital of Xinjiang Uygur autononous region from January 2010 to December 2014 were chosen to be analyzed retrospectively.37 cases in observation group were treated with low molecular heparin (LMWH) in combination with warfarin, and 43 cases in control group were treated with warfarin.The clinical curative effect between two groups was compared post-treatment.Results The effective rate in observation group was 91.89%, which was significantly higher than 67.44% in control group (P<0.05) .The recanalization rate of involved intracerebral venous in observation group was 89.19%, which was significantly higher than 67.29% in control group(P<0.05).After treatment, the prothrombin time (PT), thrombin time (TT) and activated partial thromboplastin time (APTT) were higher and fibrinogen (FBG) in both groups was lower than those pre-treatment(P<0.05).The PT and APTT was higher and FBG was lower in observation group than those in control group(P<0.05).Conclusion Low molecular weight heparin in combination with warfarin worked well than single warfarin in the treatment of intracranial venous sinus thrombosis.
