CAJ | 학술논문

目的:探讨胎儿颈项透明层厚度( nuchal translucency,NT)超声检查在早孕期胎儿筛查中的应用价值. 方法:选取接受早孕期胎儿筛查的孕妇1 008例(胎儿1 031例)作为研究对象,对胎儿NT进行超声检查,并对NT增厚的患者进行染色体核型分析. 对NT增厚但染色体核型分析正常的患者进行超声随访,观察胎儿结局. 结果:(1)1 008例孕妇中,974例孕妇成功进行了NT检查,其中NT异常增厚的胎儿共23例,颈项透明层厚度为(4. 3 ± 1. 3)mm,占2. 3 %;(2)正常胎儿的颈项透明层厚度为(1.7 ±0.8)mm,异常胎儿的颈项透明层厚度为(3.5 ±1.1)mm,高于正常胎儿( P <0.05);(3)23例NT异常增厚的胎儿中,有7例胎儿染色体核型异常,包括4例21-三体综合征、2例18-三体综合征和1例13-三体综合征,其余16例经超声随诊检查,有14例无异常现象,有1例水囊状淋巴管瘤和1例法洛四联症. 结论:在早孕期进行胎儿NT超声检查,能有效筛查出染色体核型异常的高危胎儿,具有较高的临床应用价值.
목적:탐토태인경항투명층후도( nuchal translucency,NT)초성검사재조잉기태인사사중적응용개치. 방법:선취접수조잉기태인사사적잉부1 008례(태인1 031례)작위연구대상,대태인NT진행초성검사,병대NT증후적환자진행염색체핵형분석. 대NT증후단염색체핵형분석정상적환자진행초성수방,관찰태인결국. 결과:(1)1 008례잉부중,974례잉부성공진행료NT검사,기중NT이상증후적태인공23례,경항투명층후도위(4. 3 ± 1. 3)mm,점2. 3 %;(2)정상태인적경항투명층후도위(1.7 ±0.8)mm,이상태인적경항투명층후도위(3.5 ±1.1)mm,고우정상태인( P <0.05);(3)23례NT이상증후적태인중,유7례태인염색체핵형이상,포괄4례21-삼체종합정、2례18-삼체종합정화1례13-삼체종합정,기여16례경초성수진검사,유14례무이상현상,유1례수낭상림파관류화1례법락사련증. 결론:재조잉기진행태인NT초성검사,능유효사사출염색체핵형이상적고위태인,구유교고적림상응용개치.
Objective:to discuss the application value of ultrasound in screening abnormality in fetal nuchal translucency( NT) in ear-ly pregnancy. Methods:1 008 pregnant women (1 031 fetuses) who received the screening in early pregnancy were selected;fetal NT was examined by ultrasound ;karyotype analysis was made about the patients with NT thickening;the patients with NT thickening but normal karyotype analysis were followed up. Results:(1). Among the 1008 pregnant women, 974 successfully received NT examination, 23 of whom were diagnosed as NT abnormal thickening with thickness being(4. 3 ± 1. 3)mm, accounting for 2. 3%. (2). Thickness of normal fetal NT is(1. 7 ± 0. 8)mm, while that of abnormal fetal NT is(3. 5 ± 1. 1)mm, the difference between which being significant ( P <0. 05). (3). Among the 23 fetuses with NT thickness, 7 fetuses were abnormal in the karyotype, including 4 with trisomy 21 syndrome, 2 with trisomy 18 syndrome and 1 with trisomy 13 syndrome and among the rest 16 fetuses who were examined by ultrasound, 14 fetuses were normal, with 1 fetus with water-cystic lymphangioma and tetralogy of Fallot respectively. Conclusion:Ultrasound examination of fetal NT in early pregnancy can effectively screen out the fetuses at risk of abnormal karyotype, which is very valuable in clinical application.