包头医学院学报
包頭醫學院學報
포두의학원학보
Journal of Baotou Medical College
2015年
11期
27-29
,共3页
乳腺癌%雌激素受体%孕激素受体%人表皮生长因子受体-2%超声征象
乳腺癌%雌激素受體%孕激素受體%人錶皮生長因子受體-2%超聲徵象
유선암%자격소수체%잉격소수체%인표피생장인자수체-2%초성정상
Breast cancer%Estrogen receptor (ER)%Progesterone receptor (PR)%Human epidermal growth factor receptor -2(HER-2)%Ultrasound images
目的:探讨乳腺癌雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)、人表皮生长因子受体-2 (human epidermal growth factor receptor-2,HER-2)表达的相关性及与其超声征象之间的关系,为乳腺癌的诊断、治疗和预后提供可靠的依据. 方法:收集2014年3月至2015年3月期间于包头医学院第一附属医院就诊的87例女性原发性乳腺癌病例,术前做超声检查,术后行免疫组化检测乳腺癌组织中ER、PR、HER-2的表达,用统计学方法研究乳腺癌免疫组化指标与其超声征象的关联性. 结果:87例乳腺癌肿块其ER、PR、HER-2的阳性表达率分别为71. 3 %、69. 0 %、59. 8 %. ER、PR和HER-2间有相关性,ER与PR表达呈正相关(P < 0. 05) ,HER-2与PR表达呈负相关( P <0. 05),肿块内部微钙化与ER、PR阳性表达呈负相关( P <0. 05);边缘"毛刺征"与ER、PR阳性表达呈正相关( P <0. 05);肿块内部血流丰富程度与HER-2阳性表达呈正相关( P <0. 05).结论:ER、PR、HER-2在乳腺癌中的表达既相互独立又相互关联,且与乳腺癌的超声征象相关,通过多项指标联合检测,会更准确地判断乳腺癌的预后,并可以为靶向药物的个体化治疗提供参考依据.
目的:探討乳腺癌雌激素受體(estrogen receptor,ER)、孕激素受體(progesterone receptor,PR)、人錶皮生長因子受體-2 (human epidermal growth factor receptor-2,HER-2)錶達的相關性及與其超聲徵象之間的關繫,為乳腺癌的診斷、治療和預後提供可靠的依據. 方法:收集2014年3月至2015年3月期間于包頭醫學院第一附屬醫院就診的87例女性原髮性乳腺癌病例,術前做超聲檢查,術後行免疫組化檢測乳腺癌組織中ER、PR、HER-2的錶達,用統計學方法研究乳腺癌免疫組化指標與其超聲徵象的關聯性. 結果:87例乳腺癌腫塊其ER、PR、HER-2的暘性錶達率分彆為71. 3 %、69. 0 %、59. 8 %. ER、PR和HER-2間有相關性,ER與PR錶達呈正相關(P < 0. 05) ,HER-2與PR錶達呈負相關( P <0. 05),腫塊內部微鈣化與ER、PR暘性錶達呈負相關( P <0. 05);邊緣"毛刺徵"與ER、PR暘性錶達呈正相關( P <0. 05);腫塊內部血流豐富程度與HER-2暘性錶達呈正相關( P <0. 05).結論:ER、PR、HER-2在乳腺癌中的錶達既相互獨立又相互關聯,且與乳腺癌的超聲徵象相關,通過多項指標聯閤檢測,會更準確地判斷乳腺癌的預後,併可以為靶嚮藥物的箇體化治療提供參攷依據.
목적:탐토유선암자격소수체(estrogen receptor,ER)、잉격소수체(progesterone receptor,PR)、인표피생장인자수체-2 (human epidermal growth factor receptor-2,HER-2)표체적상관성급여기초성정상지간적관계,위유선암적진단、치료화예후제공가고적의거. 방법:수집2014년3월지2015년3월기간우포두의학원제일부속의원취진적87례녀성원발성유선암병례,술전주초성검사,술후행면역조화검측유선암조직중ER、PR、HER-2적표체,용통계학방법연구유선암면역조화지표여기초성정상적관련성. 결과:87례유선암종괴기ER、PR、HER-2적양성표체솔분별위71. 3 %、69. 0 %、59. 8 %. ER、PR화HER-2간유상관성,ER여PR표체정정상관(P < 0. 05) ,HER-2여PR표체정부상관( P <0. 05),종괴내부미개화여ER、PR양성표체정부상관( P <0. 05);변연"모자정"여ER、PR양성표체정정상관( P <0. 05);종괴내부혈류봉부정도여HER-2양성표체정정상관( P <0. 05).결론:ER、PR、HER-2재유선암중적표체기상호독립우상호관련,차여유선암적초성정상상관,통과다항지표연합검측,회경준학지판단유선암적예후,병가이위파향약물적개체화치료제공삼고의거.
Objective:To investigate the correlation between the expressions of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2(HER-2)and its relationship with ultrasonic images, providing a reliable basis for the diag-nosis, treatment and prognosis of breast cancer. Methods:87 female patients with primary breast cancer hospitalized in the first Affiliated Hospital of Baotou Medical College from March 2014 to March 2015 were selected and checked by ultrasonic imaging before operation. The expressions of ER, PR and HER-2 of breast cancer were detected by immuno-histochemistry after operation. The imunohistochemical in-dex of breast cancer and its correlation with ultrasonic images were studied by using statistical method. Results:The positive expression rates of ER, PR and HER-2 in the 87 cases of breast cancer were 71. 3%, 69. 0% and 59. 8% respectively. There was correlation between ER, PR and HER-2, the expressions of ER and PR being positively correlated( P <0. 05) and the expressions of HER-2 and PR being nega-tively correlated( P <0. 05). Microcalcification in the tumour was negatively correlated with the positive expressions of ER and PR ( P <0. 05);spiculation located at the edge of the tumor was positively correlated with the positive expressions of ER and PR ( P <0. 05);the degree of blood flow inside the tumor was positively correlated with the expression of HER-2 ( P <0. 05). Conclusions:The expressions of ER, PR, and HER-2 of breast cancer are independent but correlated with each other and are related with ultrasonic images of breast canc-er. Joint detection by different indexes can tell exactly the prognosis and provide a basis for individualized treatment of targeted medicine.
